Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-γ producing T cells

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) and programmed death-1 (PD-1) molecules have emerged as pivotal players in immune suppression of chronic diseases. However, their impact on the disease severity, therapeutic response and restoration of immune response in human tuberculosis remains uncl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e44728-e44728
Hauptverfasser:	Singh, Amar, Dey, Aparajita Ballave, Mohan, Anant, Sharma, Prabhat Kumar, Mitra, Dipendra Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Apoptosis Biology CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell culture Chronic illnesses Cytokines Cytometry Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Forkhead Transcription Factors - metabolism Foxp3 protein Gene expression Human behavior Humans Immune response Immune system Immunology Immunoregulation Infectious diseases Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin 4 Interleukin-4 - metabolism Lymphocytes Lymphocytes T Male Medical prognosis Medicine Middle Aged Mycobacterium tuberculosis Patients PD-1 protein PD-L1 protein Programmed Cell Death 1 Receptor - metabolism Restoration T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tropical diseases Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - pathology Viral infections Young Adult γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!