The Critical Role of Astragalus Polysaccharides for the Improvement of PPRAα-Mediated Lipotoxicity in Diabetic Cardiomyopathy

Background Obesity-related diabetes mellitus leads to increased myocardial uptake and oxidation of fatty acids, resulting in a form of cardiac dysfunction referred to as lipotoxic cardiomyopathy. We have shown previously that Astragalus polysaccharides (APS) administration was sufficient to improve...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e45541
Hauptverfasser:	Chen, Wei, Xia, Yanping, Zhao, Xuelan, Wang, Hao, Chen, Wenjie, Yu, Maohua, Li, Yiming, Ye, Hongying, Zhang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Astragalus Biology Cardiomyopathy Cardiovascular disease Diabetes Diabetes mellitus Endocrinology Fatty acids Genes Genotype & phenotype Geriatrics Glucose metabolism Heart Heart diseases Hospitals Hyperglycemia Hypotheses Laboratory animals Lipids Medical research Medicine Metabolic disorders Mice Molecular weight Mortality Myosin Oxidation Pathogenesis Peroxisome proliferator-activated receptors Polysaccharides Rodents Saccharides Studies Therapy Transcription activation Transgenic animals
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