The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells

Co-expression of erythropoietin (Epo) and erythropoietin receptor (EpoR) has been found in various non-hematopoietic cancers including hereditary and sporadic renal cell carcinomas (RCC), but the Epo/EpoR autocrine and paracrine mechanisms in tumor progression have not yet been identified. In this s...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45122
Hauptverfasser:	Wu, Pengjie, Zhang, Ning, Wang, Xi, Zhang, Chi, Li, Teng, Ning, Xianghui, Gong, Kan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Anticancer properties Apoptosis Apoptosis - drug effects Apoptosis - genetics Autocrine signalling Cancer Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell survival Cellular signal transduction Cysts Development and progression Down-regulation Erythropoietin Erythropoietin - metabolism Erythropoietin - pharmacology Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Genetic aspects Growth Growth factors Human performance Humans Hypoxia Indoles - pharmacology Invasiveness Kidney cancer Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Matrix Metalloproteinase 2 - metabolism Medicine Mice Mice, Inbred BALB C Mice, Nude Mutation Neoplasm Invasiveness Paracrine signalling Phosphorylation Physiological aspects Protein Kinase Inhibitors - pharmacology Proteins Pyrroles - pharmacology Receptors, Erythropoietin - genetics Receptors, Erythropoietin - metabolism Recombinant Proteins - pharmacology Renal cell carcinoma Retina Ribonucleic acid RNA RNA-mediated interference Signal transduction Signal Transduction - drug effects Signal Transduction - genetics siRNA Stimulation Tumorigenesis Tumors Urology
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