A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease

Inflammation in the brain plays a major role in neurodegenerative diseases. In particular, microglial cell activation is believed to be associated with the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). An increase in microglia activation has been shown in the s...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45256
Hauptverfasser:	Pabon, Mibel M, Jernberg, Jennifer N, Morganti, Josh, Contreras, Jessika, Hudson, Charles E, Klein, Ronald L, Bickford, Paula C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Algae alpha-Synuclein - adverse effects Animals Antioxidants Biology Brain Cell activation CX3C Chemokine Receptor 1 CX3CR1 protein Cyanobacteria Cytokines Dependovirus - genetics Diet Disease Models, Animal Dopamine Fractalkine Gene Expression Regulation - drug effects Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism Hydroxylase Immunohistochemistry Inflammation Inflammatory response Injections, Intraventricular Laboratory animals Male Medicine Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Microglial cells Movement disorders Natural products Neurodegeneration Neurodegenerative diseases Neurological diseases Neurons Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Neurosurgery Neurotoxicity Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - diet therapy Parkinson Disease, Secondary - metabolism Parkinson Disease, Secondary - pathology Parkinson's disease Pathogenesis Pharmacology Physiology Phytochemicals Rats Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Rodents Signal transduction Spirulina Spirulina - chemistry Substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology Synuclein Tyrosine Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism Viruses
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