Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area

Nociceptin/orphanin FQ (N/OFQ) is known to induce food intake when administered into the lateral ventricle or certain brain areas. This is somewhat contradictory to its reward-suppressing role, as food is a strong rewarding stimulus. This discrepancy may be due to the functional diversity of N/OFQ&#...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45350
Hauptverfasser:	Parsons, Matthew P, Burt, Julia, Cranford, Amanda, Alberto, Christian, Zipperlen, Katrin, Hirasawa, Michiru
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Anorexia nervosa Appetite Biology Brain Complications and side effects Dosage and administration Drug therapy Eating - drug effects Electrophysiology Experiments Food Food intake Genetic aspects Hyperpolarization Hypophagia Hypothalamic Area, Lateral - drug effects Hypothalamic Area, Lateral - metabolism Hypothalamus Hypothalamus (lateral) Immunohistochemistry KATP Channels - metabolism Kinases Localization Luteinizing hormone Male Medicine Melanin Melanin-concentrating hormone Narcotics Neurons Neurons - drug effects Neurons - metabolism Nociceptin Opioid Peptides - pharmacology Opioids Orexins Peptides Pharmacology Physiological aspects Potassium Potassium channels Protein kinase A Protein kinase C Proteins Rats Rats, Sprague-Dawley Reinforcement Rodents Signaling Sugar Ventricle Ventricles (cerebral)
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