Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25

Recently, MicroRNAs (miR) and AMP-kinase (AMPK) have emerged as prominent players in the development of cardiac hypertrophy and heart failure. We hypothesized that components of the adenosine monophosphate-activated kinase (AMPK) pathway are targeted by miRs and alter AMPK signaling during pathologi...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41574-e41574
Hauptverfasser:	Chen, Hao, Untiveros, Gustavo M, McKee, Laurel A K, Perez, Jessica, Li, Jing, Antin, Parker B, Konhilas, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenosine kinase Adenosine monophosphate Adenylate Kinase - metabolism AMP Analysis Animals Base Sequence Biology Cardiomyopathy Cardiomyopathy, Hypertrophic - drug therapy Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Cardiovascular disease Cell Line Coronary artery disease Development and progression Disease Progression Enzyme Activation - genetics Fatty acids Gene expression Heart Heart diseases Heart failure Heart hypertrophy Humans Hypertrophy Hypoxia Interrogation Kinases LKB1 protein Male Metabolism Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Targeted Therapy Myocardium - metabolism Myocardium - pathology Nitric oxide Organ Specificity Overexpression Phosphorylation Physiology Protein expression Protein-Serine-Threonine Kinases - metabolism Proteins Pulmonary hypertension Ribonucleic acid RNA Rodents Signal Transduction - genetics Signaling siRNA Up-Regulation - genetics
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