Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modeling

During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo m...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40869-e40869
Hauptverfasser:	Liu, Aiping, Yin, Xin, Shi, Liang, Li, Peng, Thornburg, Kent L, Wang, Ruikang, Rugonyi, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis Bioengineering Biology Biomechanical Phenomena Biomechanics Biomedical engineering Blood Circulation Blood Flow Velocity Blood Pressure Chick Embryo Coherence Computational fluid dynamics Computer applications Computer Science Computer Simulation Cues Cushions Defects Developmental stages Embryonic development Embryos Endocardium - metabolism Engineering Extracellular matrix Flow velocity Fluid dynamics Gene expression Genetic programs Heart Heart - physiology Heart diseases Hydrodynamics Mathematical models Mathematics Mechanical Phenomena Medical imaging Medicine Morphogenesis Movement Myocardium - metabolism Obstetrics Optical Coherence Tomography Physics Physiological aspects Residual stress Septum Shear stress Spatial distribution Stimuli Stress, Mechanical Thrombosis Time Factors Tomography Tomography, Optical Coherence Ultrasonic imaging Uncertainty Wall shear stresses
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