CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes
Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. He...
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| creator | Winhofer, Yvonne Kiefer, Florian W Handisurya, Ammon Tura, Andrea Klein, Katharina Schneider, Barbara Marculescu, Rodrig Wagner, Oswald F Pacini, Giovanni Luger, Anton Stulnig, Thomas M Kautzky-Willer, Alexandra |
| description | Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN), a key molecule in subclinical inflammation underlying insulin resistance, in gestational diabetes.
Insulin sensitivity and secretion (derived from OGTT) as well as CTX and osteopontin were investigated in 26 GDM and 52 women with normal glucose tolerance during pregnancy [CON] between 24th and 28th gestational weeks; 24 women also underwent postpartum examination.
CTX was significantly higher in GDM compared to CON (0.44±0.20 vs.0.28±0.12 ng/ml, p |
| doi_str_mv | 10.1371/journal.pone.0040947 |
| format | Article |
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Insulin sensitivity and secretion (derived from OGTT) as well as CTX and osteopontin were investigated in 26 GDM and 52 women with normal glucose tolerance during pregnancy [CON] between 24th and 28th gestational weeks; 24 women also underwent postpartum examination.
CTX was significantly higher in GDM compared to CON (0.44±0.20 vs.0.28±0.12 ng/ml, p<.0001) and positively correlated with osteocalcin (R = 0.64, p<.0001) and parameters of insulin secretion. Osteopontin plasma concentrations were decreased in GDM compared to CON (28.81±22.12 vs.37.68±19.63 ng/ml, p = 0.04), and did not show any relation to insulin secretion or sensitivity, but were significantly correlated with CRP (R = 0.3, p<0.007) and liver enzymes. Twelve weeks after delivery CTX and OPN were increased compared to pregnancy (both p<.0001) and did not differ between GDM and CON.
Our findings support the idea of a tight regulation between bone and glucose metabolism, and suggest, that less curbed CTX during pregnancy might be involved in osteocalcin-mediated amelioration of insulin secretion in GDM. On the other hand, osteopontin was unrelated to insulin resistance in GDM, but associated with inflammatory markers and liver enzymes in all women.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0040947</identifier><identifier>PMID: 22844418</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biocompatibility ; Biology ; Biomarkers - blood ; Biomedical engineering ; Blood Glucose - metabolism ; Bone resorption ; Bone Resorption - blood ; Case-Control Studies ; Cholesterol ; Collagen ; Collagen - blood ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes, Gestational - blood ; Diabetes, Gestational - metabolism ; Diabetes, Gestational - physiopathology ; Endocrinology ; Enzymes ; Female ; Gestational diabetes ; Glucose ; Glucose metabolism ; Glucose tolerance ; Glucose tolerance test ; Humans ; Inflammation ; Insulin ; Insulin - blood ; Insulin resistance ; Insulin secretion ; Internal medicine ; Laboratories ; Liver ; Medicine ; Metabolism ; Metabolites ; Obesity ; Osteocalcin ; Osteopontin ; Osteopontin - blood ; Peptide Fragments - blood ; Physiological aspects ; Plasma ; Postpartum ; Postpartum Period - blood ; Preeclampsia ; Pregnancy ; Pregnant women ; Rodents ; Secretion ; Sensitivity ; Studies ; Type 2 diabetes ; Women's health ; Womens health</subject><ispartof>PloS one, 2012-07, Vol.7 (7), p.e40947-e40947</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Winhofer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Winhofer et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-7913c9688d938d80b43f02ce99f3d45151cf5e15514091415841b164963370ab3</citedby><cites>FETCH-LOGICAL-c593t-7913c9688d938d80b43f02ce99f3d45151cf5e15514091415841b164963370ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402470/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402470/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22844418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winhofer, Yvonne</creatorcontrib><creatorcontrib>Kiefer, Florian W</creatorcontrib><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Tura, Andrea</creatorcontrib><creatorcontrib>Klein, Katharina</creatorcontrib><creatorcontrib>Schneider, Barbara</creatorcontrib><creatorcontrib>Marculescu, Rodrig</creatorcontrib><creatorcontrib>Wagner, Oswald F</creatorcontrib><creatorcontrib>Pacini, Giovanni</creatorcontrib><creatorcontrib>Luger, Anton</creatorcontrib><creatorcontrib>Stulnig, Thomas M</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><title>CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN), a key molecule in subclinical inflammation underlying insulin resistance, in gestational diabetes.
Insulin sensitivity and secretion (derived from OGTT) as well as CTX and osteopontin were investigated in 26 GDM and 52 women with normal glucose tolerance during pregnancy [CON] between 24th and 28th gestational weeks; 24 women also underwent postpartum examination.
CTX was significantly higher in GDM compared to CON (0.44±0.20 vs.0.28±0.12 ng/ml, p<.0001) and positively correlated with osteocalcin (R = 0.64, p<.0001) and parameters of insulin secretion. Osteopontin plasma concentrations were decreased in GDM compared to CON (28.81±22.12 vs.37.68±19.63 ng/ml, p = 0.04), and did not show any relation to insulin secretion or sensitivity, but were significantly correlated with CRP (R = 0.3, p<0.007) and liver enzymes. Twelve weeks after delivery CTX and OPN were increased compared to pregnancy (both p<.0001) and did not differ between GDM and CON.
Our findings support the idea of a tight regulation between bone and glucose metabolism, and suggest, that less curbed CTX during pregnancy might be involved in osteocalcin-mediated amelioration of insulin secretion in GDM. On the other hand, osteopontin was unrelated to insulin resistance in GDM, but associated with inflammatory markers and liver enzymes in all women.</description><subject>Adult</subject><subject>Biocompatibility</subject><subject>Biology</subject><subject>Biomarkers - blood</subject><subject>Biomedical engineering</subject><subject>Blood Glucose - metabolism</subject><subject>Bone resorption</subject><subject>Bone Resorption - blood</subject><subject>Case-Control Studies</subject><subject>Cholesterol</subject><subject>Collagen</subject><subject>Collagen - blood</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diabetes, Gestational - physiopathology</subject><subject>Endocrinology</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance</subject><subject>Glucose tolerance test</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Obesity</subject><subject>Osteocalcin</subject><subject>Osteopontin</subject><subject>Osteopontin - blood</subject><subject>Peptide Fragments - blood</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Postpartum</subject><subject>Postpartum Period - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Sensitivity</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><subject>Women's health</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAUjBCIlsI_QBCJSzns4uePJL5UqlYFKlXiUiRulu04u14l8WI7IP5933bTqosqH_w1M-_N0xTFeyBLYDV82YYpjrpf7sLoloRwInn9ojgFyeiiooS9fHI-Kd6ktCVEsKaqXhcnlDacc2hOi7C6_VWe2xhS6vUufS6jzhsXy7zRYxlSdgH1sx9Ln0qdUrBeZ9eWf33elK1PeYoGr-t-siG5cnBZm9D7NJRIWbuUdfYBu0SsNi679LZ41ek-uXfzflb8_Hp1u_q-uPnx7Xp1ebOwQrK8qCUwK6umaSVr2oYYzjpCrZOyYy0XIMB2woEQgL6Bg2g4GKi4rBiriTbsrPh40N31Ial5VkkBQ98VE9Ag4vqAaIPeql30g47_VNBe3T-EuFY6Zm97pzQwamnFG1nVXBrsxoC13MgOTOeoRq2LudpkBtdaN-ao-yPR45_Rb9Q6_FGME8prggLns0AMvyecmxp8sq7v9ejChH0TRpigFBhCP_0Hfd7djFprNODHLmBduxdVl7yuiQBGakQtn0Hhat3gLQar8_h-ROAHwn1iousePQJR-1g-NKP2sVRzLJH24el8HkkPOWR31azfGQ</recordid><startdate>20120723</startdate><enddate>20120723</enddate><creator>Winhofer, Yvonne</creator><creator>Kiefer, Florian W</creator><creator>Handisurya, Ammon</creator><creator>Tura, Andrea</creator><creator>Klein, Katharina</creator><creator>Schneider, Barbara</creator><creator>Marculescu, Rodrig</creator><creator>Wagner, Oswald F</creator><creator>Pacini, Giovanni</creator><creator>Luger, Anton</creator><creator>Stulnig, Thomas M</creator><creator>Kautzky-Willer, Alexandra</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120723</creationdate><title>CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes</title><author>Winhofer, Yvonne ; Kiefer, Florian W ; Handisurya, Ammon ; Tura, Andrea ; Klein, Katharina ; Schneider, Barbara ; Marculescu, Rodrig ; Wagner, Oswald F ; Pacini, Giovanni ; Luger, Anton ; Stulnig, Thomas M ; Kautzky-Willer, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-7913c9688d938d80b43f02ce99f3d45151cf5e15514091415841b164963370ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biocompatibility</topic><topic>Biology</topic><topic>Biomarkers - blood</topic><topic>Biomedical engineering</topic><topic>Blood Glucose - metabolism</topic><topic>Bone resorption</topic><topic>Bone Resorption - blood</topic><topic>Case-Control Studies</topic><topic>Cholesterol</topic><topic>Collagen</topic><topic>Collagen - blood</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diabetes, Gestational - physiopathology</topic><topic>Endocrinology</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glucose tolerance</topic><topic>Glucose tolerance test</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Insulin secretion</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Obesity</topic><topic>Osteocalcin</topic><topic>Osteopontin</topic><topic>Osteopontin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winhofer, Yvonne</au><au>Kiefer, Florian W</au><au>Handisurya, Ammon</au><au>Tura, Andrea</au><au>Klein, Katharina</au><au>Schneider, Barbara</au><au>Marculescu, Rodrig</au><au>Wagner, Oswald F</au><au>Pacini, Giovanni</au><au>Luger, Anton</au><au>Stulnig, Thomas M</au><au>Kautzky-Willer, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-07-23</date><risdate>2012</risdate><volume>7</volume><issue>7</issue><spage>e40947</spage><epage>e40947</epage><pages>e40947-e40947</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN), a key molecule in subclinical inflammation underlying insulin resistance, in gestational diabetes.
Insulin sensitivity and secretion (derived from OGTT) as well as CTX and osteopontin were investigated in 26 GDM and 52 women with normal glucose tolerance during pregnancy [CON] between 24th and 28th gestational weeks; 24 women also underwent postpartum examination.
CTX was significantly higher in GDM compared to CON (0.44±0.20 vs.0.28±0.12 ng/ml, p<.0001) and positively correlated with osteocalcin (R = 0.64, p<.0001) and parameters of insulin secretion. Osteopontin plasma concentrations were decreased in GDM compared to CON (28.81±22.12 vs.37.68±19.63 ng/ml, p = 0.04), and did not show any relation to insulin secretion or sensitivity, but were significantly correlated with CRP (R = 0.3, p<0.007) and liver enzymes. Twelve weeks after delivery CTX and OPN were increased compared to pregnancy (both p<.0001) and did not differ between GDM and CON.
Our findings support the idea of a tight regulation between bone and glucose metabolism, and suggest, that less curbed CTX during pregnancy might be involved in osteocalcin-mediated amelioration of insulin secretion in GDM. On the other hand, osteopontin was unrelated to insulin resistance in GDM, but associated with inflammatory markers and liver enzymes in all women.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22844418</pmid><doi>10.1371/journal.pone.0040947</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1344463518 |
| source | PLoS; MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Adult Biocompatibility Biology Biomarkers - blood Biomedical engineering Blood Glucose - metabolism Bone resorption Bone Resorption - blood Case-Control Studies Cholesterol Collagen Collagen - blood Development and progression Diabetes Diabetes mellitus Diabetes, Gestational - blood Diabetes, Gestational - metabolism Diabetes, Gestational - physiopathology Endocrinology Enzymes Female Gestational diabetes Glucose Glucose metabolism Glucose tolerance Glucose tolerance test Humans Inflammation Insulin Insulin - blood Insulin resistance Insulin secretion Internal medicine Laboratories Liver Medicine Metabolism Metabolites Obesity Osteocalcin Osteopontin Osteopontin - blood Peptide Fragments - blood Physiological aspects Plasma Postpartum Postpartum Period - blood Preeclampsia Pregnancy Pregnant women Rodents Secretion Sensitivity Studies Type 2 diabetes Women's health Womens health |
| title | CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T15%3A31%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CTX%20(crosslaps)%20rather%20than%20osteopontin%20is%20associated%20with%20disturbed%20glucose%20metabolism%20in%20gestational%20diabetes&rft.jtitle=PloS%20one&rft.au=Winhofer,%20Yvonne&rft.date=2012-07-23&rft.volume=7&rft.issue=7&rft.spage=e40947&rft.epage=e40947&rft.pages=e40947-e40947&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0040947&rft_dat=%3Cgale_plos_%3EA477051307%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1344463518&rft_id=info:pmid/22844418&rft_galeid=A477051307&rft_doaj_id=oai_doaj_org_article_a132c264896749b0b4b1cc4b9f1bfe2a&rfr_iscdi=true |