Mechanism of nucleic acid unwinding by SARS-CoV helicase

The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis. We determined the minimal mechanism of helicase func...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36521-e36521
Hauptverfasser:	Adedeji, Adeyemi O, Marchand, Bruno, Te Velthuis, Aartjan J W, Snijder, Eric J, Weiss, Susan, Eoff, Robert L, Singh, Kamalendra, Sarafianos, Stefan G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biochemistry Biology Catalysis Coronaviridae Coronaviruses Deinococcus radiodurans Deoxyribonucleic acid DNA DNA helicase DNA Helicases - metabolism DNA-directed RNA polymerase Double-stranded RNA Energy consumption Energy use Enzymes Foot & mouth disease Gene expression Health aspects Hepatitis Hydrolysis Immunology Infectious diseases Intermediates Laboratories Life sciences Medicine Nucleic acids Nucleic Acids - metabolism Polarity Polymerase Proteins Ribonucleic acid RNA RNA helicase RNA synthesis RNA-directed RNA polymerase SARS Virus - enzymology Severe acute respiratory syndrome Substrate Specificity Transcription Unwinding Virology Viruses
Online-Zugang:	Volltext
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