MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells

Lung cancer is the leading cause of cancer-related mortality worldwide. Radiotherapy is often applied for treating lung cancer, but it often fails because of the relative non-susceptibility of lung cancer cells to radiation. MicroRNAs (miRNAs) have been reported to modulate the radiosensitivity of l...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e62383-e62383
Hauptverfasser:	Liu, Yi-Jyun, Lin, Yu-Fen, Chen, Yi-Fan, Luo, En-Ching, Sher, Yuh-Ping, Tsai, Mong-Hsun, Chuang, Eric Y, Lai, Liang-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Apoptosis Apoptosis - genetics Apoptosis - radiation effects Bioinformatics Biology Biomedical engineering Cancer Cancer metastasis Cancer treatment Cell cycle Cell Cycle - genetics Cell Cycle - radiation effects Cell Line, Tumor Cell Survival - genetics Cell Survival - radiation effects Deoxyribonucleic acid Disease susceptibility DNA DNA damage DNA Damage - genetics Drug dosages G2 Phase Cell Cycle Checkpoints - genetics G2 Phase Cell Cycle Checkpoints - radiation effects Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Health aspects Humans Irradiation Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Melanoma Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mortality Physiology Post-irradiation Prostate Radiation Radiation (Physics) Radiation damage Radiation effects Radiation therapy Radiation Tolerance - genetics Radiation Tolerance - radiation effects Radiosensitivity Regulatory mechanisms (biology) Ribonucleic acid RNA Skin cancer Tumor cell lines Tumor cells Tumors
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