Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats

This study tested whether the glycogen-accumulating effect of chronic in vivo pharmacological 5'AMP-activated protein kinase (AMPK) activation could improve glycemic control under conditions of insulin deficiency. Male Wistar rats were rendered diabetic through the administration of streptozoto...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e62190-e62190
Hauptverfasser:	Vitzel, Kaio F, Bikopoulos, George, Hung, Steven, Pistor, Kathryn E, Patterson, Jessica D, Curi, Rui, Ceddia, Rolando B
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation Adenylate Kinase - metabolism Adiposity - drug effects AKT protein Aminoimidazole Carboxamide - administration & dosage Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP AMP-activated protein kinase Animals Biology Blood glucose Blood Glucose - metabolism Dephosphorylation Diabetes mellitus Diabetes therapy Epididymis - drug effects Epididymis - metabolism Esterification Fatty acids Fatty Acids - metabolism Glucagon Glucagon - blood Glucose Glycogen Glycogen - metabolism Glycogen Synthase - metabolism Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - metabolism Glycogen synthesis Glycolysis Hyperglycemia Hyperglycemia - blood Hyperglycemia - drug therapy Hyperglycemia - enzymology Hyperglycemia - pathology In vivo methods and tests Insulin Insulin - deficiency Insulin - metabolism Insulin - pharmacology Kinases Male Medicine Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Muscles Oxidation Oxidation-Reduction - drug effects Oxidation-reduction reactions Palmitates - metabolism Pharmacology Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Ribonucleotides - administration & dosage Ribonucleotides - pharmacology Rodents Science Skeletal muscle Streptozocin Triglycerides Triglycerides - metabolism
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