Widespread divergence of the CEACAM/PSG genes in vertebrates and humans suggests sensitivity to selection

In mammals, carcinoembryonic antigen cell adhesion molecules (CEACAMs) and pregnancy-specific glycoproteins (PSGs) play important roles in the regulation of pathogen transmission, tumorigenesis, insulin signaling turnover, and fetal-maternal interactions. However, how these genes evolved and to what...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61701-e61701
Hauptverfasser:	Chang, Chia Lin, Semyonov, Jenia, Cheng, Po Jen, Huang, Shang Yu, Park, Jae Il, Tsai, Huai-Jen, Lin, Cheng-Yung, Grützner, Frank, Soong, Yung Kuei, Cai, James J, Hsu, Sheau Yu Teddy
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Antigens, CD - genetics Biological evolution Biology Carcinoembryonic antigen Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - genetics Cellular biology Copy number Divergence Ethics Etiology Evolution Evolution, Molecular Fetuses Gene mapping Gene polymorphism Genes Genetic diversity Genomes Genomics Glycoproteins Gynecology Homology Hospitals Human populations Humans Immunoglobulins Insulin Laboratory animals Mammals Medical research Medicine Mutation Obstetrics Pathogens Polymorphism Polymorphism, Single Nucleotide - genetics Population differentiation Population genetics Populations Pregnancy Pregnancy Proteins - genetics Proteins Selection, Genetic - genetics Signaling Single nucleotide polymorphisms Single-nucleotide polymorphism Stem cells Synteny Tumorigenesis Vertebrates Zebrafish
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