A novel magnetic stimulator increases experimental pain tolerance in healthy volunteers - a double-blind sham-controlled crossover study
The 'complex neural pulse'(TM) (CNP) is a neuromodulation protocol employing weak pulsed electromagnetic fields (PEMF). A pioneering paper reported an analgesic effect in healthy humans after 30 minutes of CNP-stimulation using three nested whole head coils. We aimed to devise and validate...
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| description | The 'complex neural pulse'(TM) (CNP) is a neuromodulation protocol employing weak pulsed electromagnetic fields (PEMF). A pioneering paper reported an analgesic effect in healthy humans after 30 minutes of CNP-stimulation using three nested whole head coils. We aimed to devise and validate a stimulator with a novel design entailing a multitude of small coils at known anatomical positions on a head cap, to improve applicability. The main hypothesis was that CNP delivery with this novel device would also increase heat pain thresholds. Twenty healthy volunteers were enrolled in this double-blind, sham-controlled, crossover study. Thirty minutes of PEMF (CNP) or sham was applied to the head. After one week the other treatment was given. Before and after each treatment, primary and secondary outcomes were measured. Primary outcome was heat pain threshold (HPT) measured with thermal quantitative sensory testing. Other outcomes were warmth detection threshold, and aspects of cognition, emotion and motor performance. As hypothesized heat pain threshold was significantly increased after the PEMF stimulation. All other outcomes were unaltered by the PEMF but there was a trend level reduction of cognitive performance after PEMF stimulation as measured by the digit-symbol substitution task. Results from this pilot study suggest that our device is able to stimulate the brain and to modulate its function. This is in agreement with previous studies that used similar magnetic field strengths to stimulate the brain. Specifically, pain control may be achieved with PEMF and for this analgesic effect, coil design does not appear to play a dominant role. In addition, the flexible configuration with small coils on a head cap improves clinical applicability.
Dutch Cochrane Centre NTR1093. |
| doi_str_mv | 10.1371/journal.pone.0061926 |
| format | Article |
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Dutch Cochrane Centre NTR1093.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0061926</identifier><identifier>PMID: 23620795</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analgesics ; Anesthesiology ; Biology ; Brain ; Brain research ; Care and treatment ; Clinical trials ; Cognition ; Cognitive ability ; Cognitive tasks ; Coiling ; Cross-Over Studies ; Demography ; Dopamine ; Double-Blind Method ; Double-blind studies ; Electromagnetic Fields ; Electromagnetism ; Emotions - physiology ; Female ; Handwriting ; Head ; Health ; Heat ; Humans ; Magnetic fields ; Magnetics - instrumentation ; Male ; Mediation ; Medicine ; Motor Activity - physiology ; Motor task performance ; Narcotics ; Neuromodulation ; Neurophysiology ; Neurosciences ; Pain ; Pain perception ; Pain Threshold - physiology ; Psychiatry ; Sensory testing ; Skin Physiological Phenomena ; Stimulation ; Transcranial magnetic stimulation ; Young Adult</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e61926-e61926</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Kortekaas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Kortekaas et al 2013 Kortekaas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3796ac36a432e4e1e7e5c23c4bd1cd69dee9aa0adcf16a91bbfd872d6f5738d13</citedby><cites>FETCH-LOGICAL-c692t-3796ac36a432e4e1e7e5c23c4bd1cd69dee9aa0adcf16a91bbfd872d6f5738d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631254/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631254/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23620795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Eldabe, Sam</contributor><creatorcontrib>Kortekaas, Rudie</creatorcontrib><creatorcontrib>van Nierop, Lotte E</creatorcontrib><creatorcontrib>Baas, Veroni G</creatorcontrib><creatorcontrib>Konopka, Karl-Heinz</creatorcontrib><creatorcontrib>Harbers, Marten</creatorcontrib><creatorcontrib>van der Hoeven, Johannes H</creatorcontrib><creatorcontrib>van Wijhe, Marten</creatorcontrib><creatorcontrib>Aleman, André</creatorcontrib><creatorcontrib>Maurits, Natasha M</creatorcontrib><title>A novel magnetic stimulator increases experimental pain tolerance in healthy volunteers - a double-blind sham-controlled crossover study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The 'complex neural pulse'(TM) (CNP) is a neuromodulation protocol employing weak pulsed electromagnetic fields (PEMF). A pioneering paper reported an analgesic effect in healthy humans after 30 minutes of CNP-stimulation using three nested whole head coils. We aimed to devise and validate a stimulator with a novel design entailing a multitude of small coils at known anatomical positions on a head cap, to improve applicability. The main hypothesis was that CNP delivery with this novel device would also increase heat pain thresholds. Twenty healthy volunteers were enrolled in this double-blind, sham-controlled, crossover study. Thirty minutes of PEMF (CNP) or sham was applied to the head. After one week the other treatment was given. Before and after each treatment, primary and secondary outcomes were measured. Primary outcome was heat pain threshold (HPT) measured with thermal quantitative sensory testing. Other outcomes were warmth detection threshold, and aspects of cognition, emotion and motor performance. As hypothesized heat pain threshold was significantly increased after the PEMF stimulation. All other outcomes were unaltered by the PEMF but there was a trend level reduction of cognitive performance after PEMF stimulation as measured by the digit-symbol substitution task. Results from this pilot study suggest that our device is able to stimulate the brain and to modulate its function. This is in agreement with previous studies that used similar magnetic field strengths to stimulate the brain. Specifically, pain control may be achieved with PEMF and for this analgesic effect, coil design does not appear to play a dominant role. In addition, the flexible configuration with small coils on a head cap improves clinical applicability.
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A pioneering paper reported an analgesic effect in healthy humans after 30 minutes of CNP-stimulation using three nested whole head coils. We aimed to devise and validate a stimulator with a novel design entailing a multitude of small coils at known anatomical positions on a head cap, to improve applicability. The main hypothesis was that CNP delivery with this novel device would also increase heat pain thresholds. Twenty healthy volunteers were enrolled in this double-blind, sham-controlled, crossover study. Thirty minutes of PEMF (CNP) or sham was applied to the head. After one week the other treatment was given. Before and after each treatment, primary and secondary outcomes were measured. Primary outcome was heat pain threshold (HPT) measured with thermal quantitative sensory testing. Other outcomes were warmth detection threshold, and aspects of cognition, emotion and motor performance. As hypothesized heat pain threshold was significantly increased after the PEMF stimulation. All other outcomes were unaltered by the PEMF but there was a trend level reduction of cognitive performance after PEMF stimulation as measured by the digit-symbol substitution task. Results from this pilot study suggest that our device is able to stimulate the brain and to modulate its function. This is in agreement with previous studies that used similar magnetic field strengths to stimulate the brain. Specifically, pain control may be achieved with PEMF and for this analgesic effect, coil design does not appear to play a dominant role. In addition, the flexible configuration with small coils on a head cap improves clinical applicability.
Dutch Cochrane Centre NTR1093.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23620795</pmid><doi>10.1371/journal.pone.0061926</doi><tpages>e61926</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-04, Vol.8 (4), p.e61926-e61926 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1344033317 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analgesics Anesthesiology Biology Brain Brain research Care and treatment Clinical trials Cognition Cognitive ability Cognitive tasks Coiling Cross-Over Studies Demography Dopamine Double-Blind Method Double-blind studies Electromagnetic Fields Electromagnetism Emotions - physiology Female Handwriting Head Health Heat Humans Magnetic fields Magnetics - instrumentation Male Mediation Medicine Motor Activity - physiology Motor task performance Narcotics Neuromodulation Neurophysiology Neurosciences Pain Pain perception Pain Threshold - physiology Psychiatry Sensory testing Skin Physiological Phenomena Stimulation Transcranial magnetic stimulation Young Adult |
| title | A novel magnetic stimulator increases experimental pain tolerance in healthy volunteers - a double-blind sham-controlled crossover study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T16%3A13%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20magnetic%20stimulator%20increases%20experimental%20pain%20tolerance%20in%20healthy%20volunteers%20-%20a%20double-blind%20sham-controlled%20crossover%20study&rft.jtitle=PloS%20one&rft.au=Kortekaas,%20Rudie&rft.date=2013-04-19&rft.volume=8&rft.issue=4&rft.spage=e61926&rft.epage=e61926&rft.pages=e61926-e61926&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0061926&rft_dat=%3Cgale_plos_%3EA478215445%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1344033317&rft_id=info:pmid/23620795&rft_galeid=A478215445&rft_doaj_id=oai_doaj_org_article_3f08d45b3d9f4b09b95cc22289022bdb&rfr_iscdi=true |