Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair
Repair success for injuries to the flexor tendon in the hand is often limited by the in vivo behaviour of the suture used for repair. Common problems associated with the choice of suture material include increased risk of infection, foreign body reactions, and inappropriate mechanical responses, par...
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| creator | Hennecke, Kathleen Redeker, Joern Kuhbier, Joern W Strauss, Sarah Allmeling, Christina Kasper, Cornelia Reimers, Kerstin Vogt, Peter M |
| description | Repair success for injuries to the flexor tendon in the hand is often limited by the in vivo behaviour of the suture used for repair. Common problems associated with the choice of suture material include increased risk of infection, foreign body reactions, and inappropriate mechanical responses, particularly decreases in mechanical properties over time. Improved suture materials are therefore needed. As high-performance materials with excellent tensile strength, spider silk fibres are an extremely promising candidate for use in surgical sutures. However, the mechanical behaviour of sutures comprised of individual silk fibres braided together has not been thoroughly investigated. In the present study, we characterise the maximum tensile strength, stress, strain, elastic modulus, and fatigue response of silk sutures produced using different braiding methods to investigate the influence of braiding on the tensile properties of the sutures. The mechanical properties of conventional surgical sutures are also characterised to assess whether silk offers any advantages over conventional suture materials. The results demonstrate that braiding single spider silk fibres together produces strong sutures with excellent fatigue behaviour; the braided silk sutures exhibited tensile strengths comparable to those of conventional sutures and no loss of strength over 1000 fatigue cycles. In addition, the braiding technique had a significant influence on the tensile properties of the braided silk sutures. These results suggest that braided spider silk could be suitable for use as sutures in flexor tendon repair, providing similar tensile behaviour and improved fatigue properties compared with conventional suture materials. |
| doi_str_mv | 10.1371/journal.pone.0061100 |
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Common problems associated with the choice of suture material include increased risk of infection, foreign body reactions, and inappropriate mechanical responses, particularly decreases in mechanical properties over time. Improved suture materials are therefore needed. As high-performance materials with excellent tensile strength, spider silk fibres are an extremely promising candidate for use in surgical sutures. However, the mechanical behaviour of sutures comprised of individual silk fibres braided together has not been thoroughly investigated. In the present study, we characterise the maximum tensile strength, stress, strain, elastic modulus, and fatigue response of silk sutures produced using different braiding methods to investigate the influence of braiding on the tensile properties of the sutures. The mechanical properties of conventional surgical sutures are also characterised to assess whether silk offers any advantages over conventional suture materials. The results demonstrate that braiding single spider silk fibres together produces strong sutures with excellent fatigue behaviour; the braided silk sutures exhibited tensile strengths comparable to those of conventional sutures and no loss of strength over 1000 fatigue cycles. In addition, the braiding technique had a significant influence on the tensile properties of the braided silk sutures. These results suggest that braided spider silk could be suitable for use as sutures in flexor tendon repair, providing similar tensile behaviour and improved fatigue properties compared with conventional suture materials.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0061100</identifier><identifier>PMID: 23613793</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal behavior ; Biocompatibility ; Biomechanical Phenomena ; Biomechanics ; Biomedical materials ; Braiding ; Cell growth ; Elastic Modulus ; Elasticity ; Fatigue ; Fibers ; Fibroins - chemistry ; Fibroins - ultrastructure ; Health aspects ; Health risks ; Humidity ; In vivo methods and tests ; Injury prevention ; Materials Science ; Materials selection ; Materials Testing ; Mechanical properties ; Medicine ; Modulus of elasticity ; Nephila clavipes ; Physics ; Polyamides ; Polypropylenes - chemistry ; Proteins ; Repair ; Silk ; Spiders ; Strain ; Stress, Mechanical ; Surgery ; Sutures ; Tendon Injuries - surgery ; Tendon repair ; Tendons ; Tensile properties ; Tensile Strength ; Wound Healing</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e61100-e61100</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Hennecke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Hennecke et al 2013 Hennecke et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b50d1ab750333075dc87517c3117ebab0f8e60f913274deacbf2e8a69232066c3</citedby><cites>FETCH-LOGICAL-c692t-b50d1ab750333075dc87517c3117ebab0f8e60f913274deacbf2e8a69232066c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629086/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629086/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23613793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Roeder, Ryan K.</contributor><creatorcontrib>Hennecke, Kathleen</creatorcontrib><creatorcontrib>Redeker, Joern</creatorcontrib><creatorcontrib>Kuhbier, Joern W</creatorcontrib><creatorcontrib>Strauss, Sarah</creatorcontrib><creatorcontrib>Allmeling, Christina</creatorcontrib><creatorcontrib>Kasper, Cornelia</creatorcontrib><creatorcontrib>Reimers, Kerstin</creatorcontrib><creatorcontrib>Vogt, Peter M</creatorcontrib><title>Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Repair success for injuries to the flexor tendon in the hand is often limited by the in vivo behaviour of the suture used for repair. Common problems associated with the choice of suture material include increased risk of infection, foreign body reactions, and inappropriate mechanical responses, particularly decreases in mechanical properties over time. Improved suture materials are therefore needed. As high-performance materials with excellent tensile strength, spider silk fibres are an extremely promising candidate for use in surgical sutures. However, the mechanical behaviour of sutures comprised of individual silk fibres braided together has not been thoroughly investigated. In the present study, we characterise the maximum tensile strength, stress, strain, elastic modulus, and fatigue response of silk sutures produced using different braiding methods to investigate the influence of braiding on the tensile properties of the sutures. The mechanical properties of conventional surgical sutures are also characterised to assess whether silk offers any advantages over conventional suture materials. The results demonstrate that braiding single spider silk fibres together produces strong sutures with excellent fatigue behaviour; the braided silk sutures exhibited tensile strengths comparable to those of conventional sutures and no loss of strength over 1000 fatigue cycles. In addition, the braiding technique had a significant influence on the tensile properties of the braided silk sutures. These results suggest that braided spider silk could be suitable for use as sutures in flexor tendon repair, providing similar tensile behaviour and improved fatigue properties compared with conventional suture materials.</description><subject>Animal behavior</subject><subject>Biocompatibility</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical materials</subject><subject>Braiding</subject><subject>Cell growth</subject><subject>Elastic Modulus</subject><subject>Elasticity</subject><subject>Fatigue</subject><subject>Fibers</subject><subject>Fibroins - chemistry</subject><subject>Fibroins - ultrastructure</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humidity</subject><subject>In vivo methods and tests</subject><subject>Injury prevention</subject><subject>Materials Science</subject><subject>Materials selection</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Modulus of elasticity</subject><subject>Nephila clavipes</subject><subject>Physics</subject><subject>Polyamides</subject><subject>Polypropylenes - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hennecke, Kathleen</au><au>Redeker, Joern</au><au>Kuhbier, Joern W</au><au>Strauss, Sarah</au><au>Allmeling, Christina</au><au>Kasper, Cornelia</au><au>Reimers, Kerstin</au><au>Vogt, Peter M</au><au>Roeder, Ryan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-17</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e61100</spage><epage>e61100</epage><pages>e61100-e61100</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Repair success for injuries to the flexor tendon in the hand is often limited by the in vivo behaviour of the suture used for repair. Common problems associated with the choice of suture material include increased risk of infection, foreign body reactions, and inappropriate mechanical responses, particularly decreases in mechanical properties over time. Improved suture materials are therefore needed. As high-performance materials with excellent tensile strength, spider silk fibres are an extremely promising candidate for use in surgical sutures. However, the mechanical behaviour of sutures comprised of individual silk fibres braided together has not been thoroughly investigated. In the present study, we characterise the maximum tensile strength, stress, strain, elastic modulus, and fatigue response of silk sutures produced using different braiding methods to investigate the influence of braiding on the tensile properties of the sutures. The mechanical properties of conventional surgical sutures are also characterised to assess whether silk offers any advantages over conventional suture materials. The results demonstrate that braiding single spider silk fibres together produces strong sutures with excellent fatigue behaviour; the braided silk sutures exhibited tensile strengths comparable to those of conventional sutures and no loss of strength over 1000 fatigue cycles. In addition, the braiding technique had a significant influence on the tensile properties of the braided silk sutures. These results suggest that braided spider silk could be suitable for use as sutures in flexor tendon repair, providing similar tensile behaviour and improved fatigue properties compared with conventional suture materials.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23613793</pmid><doi>10.1371/journal.pone.0061100</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal behavior Biocompatibility Biomechanical Phenomena Biomechanics Biomedical materials Braiding Cell growth Elastic Modulus Elasticity Fatigue Fibers Fibroins - chemistry Fibroins - ultrastructure Health aspects Health risks Humidity In vivo methods and tests Injury prevention Materials Science Materials selection Materials Testing Mechanical properties Medicine Modulus of elasticity Nephila clavipes Physics Polyamides Polypropylenes - chemistry Proteins Repair Silk Spiders Strain Stress, Mechanical Surgery Sutures Tendon Injuries - surgery Tendon repair Tendons Tensile properties Tensile Strength Wound Healing |
| title | Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair |
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