Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination

The Step trial raised the possibility that uncircumcised men with pre-existing Ad5 neutralizing antibodies carried an increased risk of HIV infection after vaccination. Thus, understanding Ad seropositivity in humans is important to the development of an AIDS vaccine. Here, we analyze the impact of...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e33969-e33969
Hauptverfasser:	Cheng, Cheng, Wang, Lingshu, Wang, LingShu, Gall, Jason G D, Nason, Martha, Schwartz, Richard M, McElrath, M Juliana, DeRosa, Steven C, Hural, John, Corey, Lawrence, Buchbinder, Susan P, Nabel, Gary J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adenoviridae - genetics Adenoviridae - immunology Adenoviridae Infections - complications Adenoviridae Infections - immunology AIDS AIDS vaccines AIDS Vaccines - immunology Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - immunology Antigens Biological activity Biology Cancer Capsid protein Capsid Proteins - genetics Capsid Proteins - immunology Capsids Case-Control Studies CD8 antigen Clinical trials Dietary fiber Enzyme-Linked Immunosorbent Assay Fibers Gene expression Gene therapy Genetic Vectors - genetics Genetic Vectors - immunology Health aspects Health risks HIV HIV infections HIV Infections - etiology HIV Seropositivity - immunology HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immune response Immunity Immunity, Cellular - immunology Immunoglobulins Impact analysis Infection Infections Infectious diseases Male Medical research Medicine Neutralizing Proteins Risk Risk Factors Seroepidemiologic Studies Serotypes T-Lymphocytes - immunology Tumors Vaccination Vaccines Vectors (Biology) Viral proteins
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