Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections
Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized w...
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| Veröffentlicht in: | PloS one 2012-04, Vol.7 (4), p.e34390-e34390 |
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| creator | Banchereau, Romain Jordan-Villegas, Alejandro Ardura, Monica Mejias, Asuncion Baldwin, Nicole Xu, Hui Saye, Elizabeth Rossello-Urgell, Jose Nguyen, Phuong Blankenship, Derek Creech, Clarence B Pascual, Virginia Banchereau, Jacques Chaussabel, Damien Ramilo, Octavio |
| description | Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations. |
| doi_str_mv | 10.1371/journal.pone.0034390 |
| format | Article |
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To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0034390</identifier><identifier>PMID: 22496797</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive immunity ; Adaptive Immunity - genetics ; Adolescent ; B cells ; Bacteria ; Bacterial infections ; Biology ; Biomarkers - metabolism ; Blood ; Blood Proteins - analysis ; Blood tests ; Care and treatment ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Children & youth ; Community-Acquired Infections - immunology ; Cytokines ; Dendritic cells ; Female ; Gene expression ; Gene Expression Profiling ; Genes ; Genetic aspects ; Hematopoiesis ; Hemopoiesis ; Hospitals ; Host-Pathogen Interactions - immunology ; Humans ; Immunity ; Immunity, Innate - genetics ; Immunology ; Infant ; Infection ; Infections ; Infectious diseases ; Inflammatory bowel disease ; Innate immunity ; Male ; Medicine ; Morbidity ; Mortality ; Neutrophils ; Oligonucleotide Array Sequence Analysis ; Overexpression ; Pathogenesis ; Pediatrics ; Perturbation methods ; Sampling ; Staphylococcal infections ; Staphylococcal Infections - genetics ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - genetics ; Staphylococcus aureus - immunology ; Staphylococcus aureus - isolation & purification ; Staphylococcus infections ; Systems analysis ; Thrombosis ; Transcription ; Transcription (Genetics)</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e34390-e34390</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Banchereau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Banchereau et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-dc1fad57560ef00424449df8050e40506e5a901eab368de4ce0ec39d54fdfcb63</citedby><cites>FETCH-LOGICAL-c725t-dc1fad57560ef00424449df8050e40506e5a901eab368de4ce0ec39d54fdfcb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319567/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319567/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22496797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Otto, Michael</contributor><creatorcontrib>Banchereau, Romain</creatorcontrib><creatorcontrib>Jordan-Villegas, Alejandro</creatorcontrib><creatorcontrib>Ardura, Monica</creatorcontrib><creatorcontrib>Mejias, Asuncion</creatorcontrib><creatorcontrib>Baldwin, Nicole</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Saye, Elizabeth</creatorcontrib><creatorcontrib>Rossello-Urgell, Jose</creatorcontrib><creatorcontrib>Nguyen, Phuong</creatorcontrib><creatorcontrib>Blankenship, Derek</creatorcontrib><creatorcontrib>Creech, Clarence B</creatorcontrib><creatorcontrib>Pascual, Virginia</creatorcontrib><creatorcontrib>Banchereau, Jacques</creatorcontrib><creatorcontrib>Chaussabel, Damien</creatorcontrib><creatorcontrib>Ramilo, Octavio</creatorcontrib><title>Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.</description><subject>Adaptive immunity</subject><subject>Adaptive Immunity - genetics</subject><subject>Adolescent</subject><subject>B cells</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Biology</subject><subject>Biomarkers - metabolism</subject><subject>Blood</subject><subject>Blood Proteins - analysis</subject><subject>Blood tests</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Community-Acquired Infections - immunology</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Hematopoiesis</subject><subject>Hemopoiesis</subject><subject>Hospitals</subject><subject>Host-Pathogen Interactions - 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immunology</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Staphylococcus infections</subject><subject>Systems analysis</subject><subject>Thrombosis</subject><subject>Transcription</subject><subject>Transcription (Genetics)</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk2Fr1DAYx4sobp5-A9GCIPrizqRJ0-aNMIa6g8HAqW9Dmj65y5E2XZJO9zH8xqa727iTvRiFNrS_55_0__yfLHuN0QKTCn_auNH30i4G18MCIUIJR0-yY8xJMWcFIk_31kfZixA2CJWkZux5dlQUlLOKV8fZ3zMXYm66buwhj172QXkzROOSdD54p42FkHvQFlTM4xrya-mNbIw18SY3fa6s6Y1KcGsCyAB5J3ujIUQ5iYQJGdIS-hjy3yau88soh_WNdcopNYZcjh7GCdNpg6niZfZMSxvg1e45y35-_fLj9Gx-fvFteXpyPldVUcZ5q7CWbVmVDIFGiBaUUt7qGpUIaLoxKCVHGGRDWN0CVYBAEd6WVLdaNYzMsrdb3cG6IHZuBoEJRZyWRTERyy3ROrkRgzed9DfCSSNuXzi_EtJHoywIWvC6xJRQLRvaNrpmLS-bhuma1owSlbQ-73Ybmw5alfzw0h6IHn7pzVqs3LUgBPOSVUngw07Au6sx-Ss6ExRYK3twYzo3whVnmFf0EWjyCzFMcELf_Yc-bMSOWsn0r6lVLh1RTaLihFYVprxOAZxliweodLXQGZVSOmXpsODjQUFiIvyJKzmGIJaX3x_PXvw6ZN_vsWuQNq6Ds-NtvA5BugWVdyGkkN_3AyMxDdmdG2IaMrEbslT2Zr-X90V3U0X-AcYDJXI</recordid><startdate>20120404</startdate><enddate>20120404</enddate><creator>Banchereau, Romain</creator><creator>Jordan-Villegas, Alejandro</creator><creator>Ardura, Monica</creator><creator>Mejias, Asuncion</creator><creator>Baldwin, Nicole</creator><creator>Xu, Hui</creator><creator>Saye, Elizabeth</creator><creator>Rossello-Urgell, Jose</creator><creator>Nguyen, Phuong</creator><creator>Blankenship, Derek</creator><creator>Creech, Clarence B</creator><creator>Pascual, Virginia</creator><creator>Banchereau, Jacques</creator><creator>Chaussabel, Damien</creator><creator>Ramilo, Octavio</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120404</creationdate><title>Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections</title><author>Banchereau, Romain ; Jordan-Villegas, Alejandro ; Ardura, Monica ; Mejias, Asuncion ; Baldwin, Nicole ; Xu, Hui ; Saye, Elizabeth ; Rossello-Urgell, Jose ; Nguyen, Phuong ; Blankenship, Derek ; Creech, Clarence B ; Pascual, Virginia ; Banchereau, Jacques ; Chaussabel, Damien ; Ramilo, Octavio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-dc1fad57560ef00424449df8050e40506e5a901eab368de4ce0ec39d54fdfcb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptive immunity</topic><topic>Adaptive Immunity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banchereau, Romain</au><au>Jordan-Villegas, Alejandro</au><au>Ardura, Monica</au><au>Mejias, Asuncion</au><au>Baldwin, Nicole</au><au>Xu, Hui</au><au>Saye, Elizabeth</au><au>Rossello-Urgell, Jose</au><au>Nguyen, Phuong</au><au>Blankenship, Derek</au><au>Creech, Clarence B</au><au>Pascual, Virginia</au><au>Banchereau, Jacques</au><au>Chaussabel, Damien</au><au>Ramilo, Octavio</au><au>Otto, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-04-04</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>e34390</spage><epage>e34390</epage><pages>e34390-e34390</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22496797</pmid><doi>10.1371/journal.pone.0034390</doi><tpages>e34390</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1340945226 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptive immunity Adaptive Immunity - genetics Adolescent B cells Bacteria Bacterial infections Biology Biomarkers - metabolism Blood Blood Proteins - analysis Blood tests Care and treatment Case-Control Studies Child Child, Preschool Children Children & youth Community-Acquired Infections - immunology Cytokines Dendritic cells Female Gene expression Gene Expression Profiling Genes Genetic aspects Hematopoiesis Hemopoiesis Hospitals Host-Pathogen Interactions - immunology Humans Immunity Immunity, Innate - genetics Immunology Infant Infection Infections Infectious diseases Inflammatory bowel disease Innate immunity Male Medicine Morbidity Mortality Neutrophils Oligonucleotide Array Sequence Analysis Overexpression Pathogenesis Pediatrics Perturbation methods Sampling Staphylococcal infections Staphylococcal Infections - genetics Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - immunology Staphylococcus aureus - isolation & purification Staphylococcus infections Systems analysis Thrombosis Transcription Transcription (Genetics) |
| title | Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T01%3A10%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Host%20immune%20transcriptional%20profiles%20reflect%20the%20variability%20in%20clinical%20disease%20manifestations%20in%20patients%20with%20Staphylococcus%20aureus%20infections&rft.jtitle=PloS%20one&rft.au=Banchereau,%20Romain&rft.date=2012-04-04&rft.volume=7&rft.issue=4&rft.spage=e34390&rft.epage=e34390&rft.pages=e34390-e34390&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0034390&rft_dat=%3Cgale_plos_%3EA477149800%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1340945226&rft_id=info:pmid/22496797&rft_galeid=A477149800&rft_doaj_id=oai_doaj_org_article_429851434fab4dbf86d95bb6f848643c&rfr_iscdi=true |