Detection of recent HIV-1 infection using a new limiting-antigen avidity assay: potential for HIV-1 incidence estimates and avidity maturation studies

Accurate and reliable laboratory methods are needed for estimation of HIV-1 incidence to identify the high-risk populations and target and monitor prevention efforts. We previously described a single-well limiting-antigen avidity enzyme immunoassay (LAg-Avidity EIA) to detect recent HIV-1 infection....

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33328-e33328
Hauptverfasser:	Duong, Yen T, Qiu, Maofeng, De, Anindya K, Jackson, Keisha, Dobbs, Trudy, Kim, Andrea A, Nkengasong, John N, Parekh, Bharat S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines Antibodies Antibody Affinity - immunology Antigens Avidity Biology Clinical trials Coefficient of variation Constraining Disease control Enzyme immunoassay Enzymes Epidemics Estimates Health aspects Health risks HIV HIV Antibodies - blood HIV Antibodies - immunology HIV Antigens - immunology HIV Infections - blood HIV Infections - diagnosis HIV Infections - immunology HIV Seropositivity - blood HIV Seropositivity - diagnosis HIV Seropositivity - immunology HIV tests HIV-1 - growth & development HIV-1 - immunology Human immunodeficiency virus Humans Immunization Immunoassay Immunoenzyme Techniques - methods Immunoglobulin G Immunoglobulins Incidence Infections Kinetics Laboratories Laboratory methods Longitudinal Studies Maturation Medicine Optical density Optimization Populations Prevention Proteins Quality control Reproducibility Reproducibility of Results Risk analysis Risk factors Sensitivity and Specificity Serology Studies Surveillance Tuberculosis Viral Load
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