$Genome-wide association study of treatment refractory schizophrenia in Han Chinese$

Genome-wide association study of treatment refractory schizophrenia in Han Chinese

We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04 × 10(-7)) an...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33598
Hauptverfasser:	Liou, Ying-Jay, Wang, Hui-Hung, Lee, Ming-Ta Michael, Wang, Sheng-Chang, Chiang, Hung-Lun, Chen, Cheng-Chung, Lin, Ching-Hua, Chung, Ming-Shun, Kuo, Chien-Cheng, Liao, Ding-Lieh, Wu, Ching-Kuan, Liu, Chih-Min, Liu, Yu-Li, Hwu, Hai-Gwo, Lai, I-Ching, Tsai, Shih-Jen, Chen, Chia-Hsiang, Liu, Hui-Fen, Chou, Yi-Chun, Chen, Chien-Hsiun, Chen, Yuan-Tsong, Hong, Chen-Jee, Wu, Jer-Yuarn
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Adult Aged Alleles Antipsychotics Asian Continental Ancestry Group - genetics Biology Cell activation Cell Line Clinical medicine Cytokines Female Gene polymorphism Genes Genetic research Genome-wide association studies Genome-Wide Association Study Genomes Genomics Haplotypes Health sciences Hospitals Humans Leukemia Linkage Disequilibrium Loci Lymphocytes B Male Medical research Medicine Mental disorders Mental health Middle Aged Neurophysiology NF-kappa B p50 Subunit - genetics NF-kappa B p50 Subunit - metabolism Polymorphism Polymorphism, Single Nucleotide Population Protein kinase Protein kinases Psychiatry Psychosis Psychotropic drugs Regulation Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Signal transduction Signaling Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Taiwan Threonine Veterans
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