Heparanase affects food intake and regulates energy balance in mice

Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan. The proteoglycan can be structurally modified by the enzyme heparanase. Here we...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e34313-e34313
Hauptverfasser:	Karlsson-Lindahl, Linda, Schmidt, Linnéa, Haage, David, Hansson, Caroline, Taube, Magdalena, Egecioglu, Emil, Egeciouglu, Emil, Tan, Ying-xia, Admyre, Therese, Jansson, John-Olov, Vlodavsky, Israel, Li, Jin-Ping, Lindahl, Ulf, Dickson, Suzanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Agouti-Related Protein Agouti-Related Protein - metabolism alpha-MSH alpha-MSH - metabolism Animals Basic Medicine Biochemistry Biology Body Composition Body composition (biology) Body fat Body Weight Cancer Crosses Crosses, Genetic deficient mice Diet diet-induced obesity Dietary Fats Eating Eating - genetics Eating - physiology Endocrinology Energy Energy balance Energy Metabolism Energy Metabolism - genetics Enzymes Enzymologic Feeding Behavior Female Food Food composition Food intake Gene Expression Regulation Gene Expression Regulation, Enzymologic Genetic Genetic modification Genetically engineered foods Genetically modified organisms genetics Glucuronidase Glucuronidase - pharmacology Heparan sulfate High fat diet House mouse in-vivo Inbred C57BL Infusions Infusions, Intraventricular Insulin resistance Intracerebroventricular administration Intraventricular Knockout Ligands Male Medicine Medicinska grundvetenskaper Melanocortin Melanocortin MC4 receptors melanocortin-4 receptor metabolism Mice Mice, Inbred C57BL Mice, Knockout Mutation Neurosciences Obesity pharmacology Physiological aspects Physiology Proteins Receptor Receptor, Melanocortin, Type 4 - genetics Receptor, Melanocortin, Type 4 - metabolism Rodents Siblings Signal Transduction Signaling Sulfate Sulfates Syndecan Syndecan-3 Syndecan-3 - metabolism transgenic expression Type 4 Weight reduction
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