The transcription factor Myt3 acts as a pro-survival factor in β-cells

We previously identified the transcription factor Myt3 as specifically expressed in pancreatic islets. Here, we sought to determine the expression and regulation of Myt3 in islets and to determine its significance in regulating islet function and survival. Myt3 expression was determined in embryonic...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51501-e51501
Hauptverfasser:	Tennant, Bryan R, Islam, Ratib, Kramer, Marabeth M, Merkulova, Yulia, Kiang, Roger L, Whiting, Cheryl J, Hoffman, Brad G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-x protein Beta2 protein Biology Cell survival Cell Survival - genetics Children & youth Chromatin Chromatin Immunoprecipitation Cytokines Diabetes DNA Primers - genetics Embryos Fluorescent Antibody Technique Gene expression Gene Expression Regulation - genetics Gene Expression Regulation - physiology Glucose Immunohistochemistry In Situ Hybridization Insulin Insulin secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Interleukin 6 Islets of Langerhans Luciferases Medicine Mice Overexpression Pancreas Penicillin Polymerase Chain Reaction RNA, Small Interfering - genetics Rodents Survival Survival factor Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Zinc Fingers - genetics
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