The congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin

β/γ-Crystallins, the major structural proteins in human lens, are highly conserved in their tertiary structures but distinct in the quaternary structures. The N- and C-terminal extensions have been proposed to play a crucial role in mediating the size of β-crystallin assembly. In this research, we i...

Ausführliche Beschreibung