Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice

In vivo studies of high dose radiation-induced crypt and intestinal stem cell (ISC) loss and subsequent regeneration are typically restricted to 5-8 days after radiation due to high mortality and immune failure. This study aimed to develop murine radiation models of complete crypt loss that permit l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51310
Hauptverfasser:	Van Landeghem, Laurianne, Blue, Randall Eric, Dehmer, Jeffrey J, Henning, Susan J, Helmrath, Michael A, Lund, Pauline Kay
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Analysis of Variance Animal models Animals Apoptosis Background radiation Biology Body weight Body weight loss Comparative analysis Crypts Damage detection Diet Drug dosages Epithelium Feeding Food intake Food, Formulated Gastroenterology Growth factors Health aspects House mouse In vivo methods and tests Inflammation Intestinal Mucosa - radiation effects Intestine Intestine, Small - cytology Intestine, Small - physiology Intestine, Small - radiation effects Laboratory animals Medicine Mice Mice, Inbred C57BL Models, Animal Motility Mutants Physiology Post-radiation Radiation Radiation (Physics) Radiation dosage Radiation effects Radiation models Regeneration Regeneration - physiology Repair Rodents Small intestine Statistics, Nonparametric Stem cells Stem Cells - radiation effects Studies Surgery Survival Transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!