Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome
The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases. In this study we focus on SP-A structure in cystic fibrosis (...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e51050-e51050 |
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| creator | Griese, Matthias Heinrich, Stephanie Ratjen, Felix Kabesch, Michael Paul, Karl Ballmann, Manfred Rietschel, Ernst Kappler, Matthias |
| description | The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases. In this study we focus on SP-A structure in cystic fibrosis (CF) compared to both healthy subjects and disease controls.
SP-A composition and function were assessed in both bronchoalveolar lavage (BAL) fluid and serum of 46 CF patients with mild disease, 25 patients with chronic bronchitis and 22 healthy subjects by gel chromatography and a functional agglutination assay. Relation of SP-A agglutination ability to disease severity of the subjects was explored.
SP-A was present in seven major oligomeric forms with the majority of SP-A being structurally organized as complex oligomeric forms. More complex oligomeric forms were associated with better SP-A function with regard to its agglutination ability. These forms were more frequently observed in BAL than in serum, but there were no differences between disease groups. In CF patients, more complex forms of SP-A were associated with better lung function.
Organizational structure of SP-A affects its functional activity and is linked to disease severity in CF. |
| doi_str_mv | 10.1371/journal.pone.0051050 |
| format | Article |
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SP-A composition and function were assessed in both bronchoalveolar lavage (BAL) fluid and serum of 46 CF patients with mild disease, 25 patients with chronic bronchitis and 22 healthy subjects by gel chromatography and a functional agglutination assay. Relation of SP-A agglutination ability to disease severity of the subjects was explored.
SP-A was present in seven major oligomeric forms with the majority of SP-A being structurally organized as complex oligomeric forms. More complex oligomeric forms were associated with better SP-A function with regard to its agglutination ability. These forms were more frequently observed in BAL than in serum, but there were no differences between disease groups. In CF patients, more complex forms of SP-A were associated with better lung function.
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SP-A composition and function were assessed in both bronchoalveolar lavage (BAL) fluid and serum of 46 CF patients with mild disease, 25 patients with chronic bronchitis and 22 healthy subjects by gel chromatography and a functional agglutination assay. Relation of SP-A agglutination ability to disease severity of the subjects was explored.
SP-A was present in seven major oligomeric forms with the majority of SP-A being structurally organized as complex oligomeric forms. More complex oligomeric forms were associated with better SP-A function with regard to its agglutination ability. These forms were more frequently observed in BAL than in serum, but there were no differences between disease groups. In CF patients, more complex forms of SP-A were associated with better lung function.
Organizational structure of SP-A affects its functional activity and is linked to disease severity in CF.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Agglutination</subject><subject>Alveoli</subject><subject>Biology</subject><subject>Bronchitis</subject><subject>Bronchoalveolar Lavage</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchus</subject><subject>Child</subject><subject>Chromatography</subject><subject>Chromatography, Gel</subject><subject>Control methods</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - metabolism</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Disease control</subject><subject>Female</subject><subject>Gel chromatography</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lung - metabolism</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Microorganisms</subject><subject>Monomers</subject><subject>Oligomerization</subject><subject>Oligomers</subject><subject>Organizational structure</subject><subject>Patients</subject><subject>Protein A</subject><subject>Proteins</subject><subject>Pulmonary Surfactant-Associated Protein A - analysis</subject><subject>Pulmonary Surfactant-Associated Protein A - metabolism</subject><subject>Respiratory function</subject><subject>Severity of Illness Index</subject><subject>Structure-function relationships</subject><subject>Surface active agents</subject><subject>Surfactant protein A</subject><subject>Surfactants</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkttq3DAQhk1padK0b1BaQyG0F7uVLEu2e1EIoYeFQKBpcytkWdrVYkuODiV5-852nbAuuSgG2Yy--efgP8teY7TEpMIfty55K_rl6KxaIkQxouhJdowbUixYgcjTg--j7EUIW4BIzdjz7KggBWFl0Rxn11fJayGjsDEfvYvK2FzkcMi7EI3MtWm9CyZ8ykMavYjeDMpDPESfZExe5cJ2-Zj6wVnh73KXonSDepk906IP6tX0Psl-ff3y8_z74uLy2-r87GIhK1rHhVYdZZo1RcEaSrFGTLZI065Crda4qCrNOiY6SqgkSku4pxXVRQ1HS9quJifZ273u2LvAp5UEjglpEAxISiBWe6JzYstH6B_a5E4Y_jfg_JoLD5P2ijOJG91QKNvqspVNjRpRk6JVUmCEhQatz1O11A6qk8pGL_qZ6PzGmg1fu9-cUFwx1IDA-0nAu5ukQuSDCVL1vbDKJei7gL4pYxUF9N0_6OPTTdRawADGagd15U6Un5VVheoS1zut5SMUPJ0ajAT_aAPxWcKHWQIwUd3GtUgh8NXVj_9nL6_n7OkBu1Gij5vg-hSNs2EOlntQgvuCV_phyRjxnf3vt8F39ueT_SHtzeEPeki69zv5A5NAAPE</recordid><startdate>20121207</startdate><enddate>20121207</enddate><creator>Griese, Matthias</creator><creator>Heinrich, Stephanie</creator><creator>Ratjen, Felix</creator><creator>Kabesch, Michael</creator><creator>Paul, Karl</creator><creator>Ballmann, Manfred</creator><creator>Rietschel, Ernst</creator><creator>Kappler, Matthias</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121207</creationdate><title>Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome</title><author>Griese, Matthias ; Heinrich, Stephanie ; Ratjen, Felix ; Kabesch, Michael ; Paul, Karl ; Ballmann, Manfred ; Rietschel, Ernst ; Kappler, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-fed56f692269551f06cb0f5d70bff1277f6d6ad535c3efcf06575f2875fb3bd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Agglutination</topic><topic>Alveoli</topic><topic>Biology</topic><topic>Bronchitis</topic><topic>Bronchoalveolar Lavage</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchus</topic><topic>Child</topic><topic>Chromatography</topic><topic>Chromatography, Gel</topic><topic>Control methods</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - metabolism</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Disease control</topic><topic>Female</topic><topic>Gel chromatography</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lung - metabolism</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Microorganisms</topic><topic>Monomers</topic><topic>Oligomerization</topic><topic>Oligomers</topic><topic>Organizational structure</topic><topic>Patients</topic><topic>Protein A</topic><topic>Proteins</topic><topic>Pulmonary Surfactant-Associated Protein A - analysis</topic><topic>Pulmonary Surfactant-Associated Protein A - metabolism</topic><topic>Respiratory function</topic><topic>Severity of Illness Index</topic><topic>Structure-function relationships</topic><topic>Surface active agents</topic><topic>Surfactant protein A</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griese, Matthias</creatorcontrib><creatorcontrib>Heinrich, Stephanie</creatorcontrib><creatorcontrib>Ratjen, Felix</creatorcontrib><creatorcontrib>Kabesch, Michael</creatorcontrib><creatorcontrib>Paul, Karl</creatorcontrib><creatorcontrib>Ballmann, Manfred</creatorcontrib><creatorcontrib>Rietschel, Ernst</creatorcontrib><creatorcontrib>Kappler, Matthias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griese, Matthias</au><au>Heinrich, Stephanie</au><au>Ratjen, Felix</au><au>Kabesch, Michael</au><au>Paul, Karl</au><au>Ballmann, Manfred</au><au>Rietschel, Ernst</au><au>Kappler, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-07</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e51050</spage><epage>e51050</epage><pages>e51050-e51050</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases. In this study we focus on SP-A structure in cystic fibrosis (CF) compared to both healthy subjects and disease controls.
SP-A composition and function were assessed in both bronchoalveolar lavage (BAL) fluid and serum of 46 CF patients with mild disease, 25 patients with chronic bronchitis and 22 healthy subjects by gel chromatography and a functional agglutination assay. Relation of SP-A agglutination ability to disease severity of the subjects was explored.
SP-A was present in seven major oligomeric forms with the majority of SP-A being structurally organized as complex oligomeric forms. More complex oligomeric forms were associated with better SP-A function with regard to its agglutination ability. These forms were more frequently observed in BAL than in serum, but there were no differences between disease groups. In CF patients, more complex forms of SP-A were associated with better lung function.
Organizational structure of SP-A affects its functional activity and is linked to disease severity in CF.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23236429</pmid><doi>10.1371/journal.pone.0051050</doi><tpages>e51050</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Agglutination Alveoli Biology Bronchitis Bronchoalveolar Lavage Bronchoalveolar Lavage Fluid - chemistry Bronchus Child Chromatography Chromatography, Gel Control methods Cystic fibrosis Cystic Fibrosis - metabolism Cystic Fibrosis - physiopathology Disease control Female Gel chromatography Humans Inflammation Lung - metabolism Lung diseases Male Medical research Medicine Microorganisms Monomers Oligomerization Oligomers Organizational structure Patients Protein A Proteins Pulmonary Surfactant-Associated Protein A - analysis Pulmonary Surfactant-Associated Protein A - metabolism Respiratory function Severity of Illness Index Structure-function relationships Surface active agents Surfactant protein A Surfactants |
| title | Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome |
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