Impaired trunk stability in individuals at high risk for Parkinson's disease
The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making i...
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| creator | Maetzler, Walter Mancini, Martina Liepelt-Scarfone, Inga Müller, Katharina Becker, Clemens van Lummel, Rob C Ainsworth, Erik Hobert, Markus Streffer, Johannes Berg, Daniela Chiari, Lorenzo |
| description | The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making it tempting to speculate that changes in sway performance may even occur at a prodromal stage, and may have the potential to serve as a prodromal marker for the disease.
Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.
Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease. |
| doi_str_mv | 10.1371/journal.pone.0032240 |
| format | Article |
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Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.
Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0032240</identifier><identifier>PMID: 22457713</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accelerometers ; Alzheimer's disease ; Alzheimers disease ; Balance ; Biofeedback ; Biology ; Biomarkers ; Biomechanics ; Brain research ; Case-Control Studies ; Cognitive ability ; Computer science ; Cross-Sectional Studies ; Disease control ; Female ; Foam ; Foams ; Geriatrics ; Health risks ; Humans ; Infection control ; Male ; Medical treatment ; Medicine ; Middle Aged ; Movement disorders ; Mutation ; Neurodegenerative diseases ; Neurology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Parkinsons disease ; Posture ; R&D ; Research & development ; Risk ; Risk Factors ; Smoothness ; Spine ; Stability ; Torso - physiopathology</subject><ispartof>PloS one, 2012-03, Vol.7 (3), p.e32240-e32240</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Maetzler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Maetzler et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-a64078d217bf075dd822935eb9234f060ec2bf80bfd8de243c61e05bebeec0783</citedby><cites>FETCH-LOGICAL-c757t-a64078d217bf075dd822935eb9234f060ec2bf80bfd8de243c61e05bebeec0783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311622/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311622/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22457713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Duda, John</contributor><creatorcontrib>Maetzler, Walter</creatorcontrib><creatorcontrib>Mancini, Martina</creatorcontrib><creatorcontrib>Liepelt-Scarfone, Inga</creatorcontrib><creatorcontrib>Müller, Katharina</creatorcontrib><creatorcontrib>Becker, Clemens</creatorcontrib><creatorcontrib>van Lummel, Rob C</creatorcontrib><creatorcontrib>Ainsworth, Erik</creatorcontrib><creatorcontrib>Hobert, Markus</creatorcontrib><creatorcontrib>Streffer, Johannes</creatorcontrib><creatorcontrib>Berg, Daniela</creatorcontrib><creatorcontrib>Chiari, Lorenzo</creatorcontrib><title>Impaired trunk stability in individuals at high risk for Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making it tempting to speculate that changes in sway performance may even occur at a prodromal stage, and may have the potential to serve as a prodromal marker for the disease.
Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.
Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease.</description><subject>Accelerometers</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Balance</subject><subject>Biofeedback</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomechanics</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Cognitive ability</subject><subject>Computer science</subject><subject>Cross-Sectional Studies</subject><subject>Disease control</subject><subject>Female</subject><subject>Foam</subject><subject>Foams</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>Humans</subject><subject>Infection control</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Mutation</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Parkinsons disease</subject><subject>Posture</subject><subject>R&D</subject><subject>Research & development</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Smoothness</subject><subject>Spine</subject><subject>Stability</subject><subject>Torso - physiopathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWLtu_2BshsHKLpLpy5J9MyhlH4FAx75uhWwdOUocK5Xksv77KYtb4tGLIYGE_LzvkY7fLHuJ0RxTgd-v3eB71c13roc5QpQQhh5lp7iiZMYJoo-P9ifZsxDWCBW05PxpdpLYQghMT7PlYrtT1oPOox_6TR6iqm1n421u-zS1vbF6UF3IVcxXtl3l3oZNbpzPvyq_sX1w_XnItQ2gAjzPnpjEwotxPct-fvr44_LLbHn1eXF5sZw1ohBxpjhDotQEi9ogUWhdElLRAuqKUGYQR9CQ2pSoNrrUQBhtOAZU1FADNElJz7LXB99d54IcGxEkprQsGaG0SMTiQGin1nLn7Vb5W-mUlX8PnG-l8tE2HUhuFDKYa1wqw5DSilCsS8y5oYoZUSWvD2O1od6CbqCPXnUT0-mX3q5k624kpRhzQpLB-Wjg3fUAIcqtDQ10nerBDUFWnLIqcSyRb_4hH37cSLUq3d_2xqWyzd5TXjAhEOOM7avOH6DS0LC1TQqNsel8Ing3ESQmwu_YqiEEufj-7f_Zq19T9u0RuwLVxVVw3RCt68MUZAew8S4ED-a-xxjJfebvuiH3mZdj5pPs1fH_uRfdhZz-Ac6s-5I</recordid><startdate>20120323</startdate><enddate>20120323</enddate><creator>Maetzler, Walter</creator><creator>Mancini, Martina</creator><creator>Liepelt-Scarfone, Inga</creator><creator>Müller, Katharina</creator><creator>Becker, Clemens</creator><creator>van Lummel, Rob C</creator><creator>Ainsworth, Erik</creator><creator>Hobert, Markus</creator><creator>Streffer, Johannes</creator><creator>Berg, Daniela</creator><creator>Chiari, Lorenzo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120323</creationdate><title>Impaired trunk stability in individuals at high risk for Parkinson's disease</title><author>Maetzler, Walter ; Mancini, Martina ; Liepelt-Scarfone, Inga ; Müller, Katharina ; Becker, Clemens ; van Lummel, Rob C ; Ainsworth, Erik ; Hobert, Markus ; Streffer, Johannes ; Berg, Daniela ; Chiari, Lorenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-a64078d217bf075dd822935eb9234f060ec2bf80bfd8de243c61e05bebeec0783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Accelerometers</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Balance</topic><topic>Biofeedback</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Biomechanics</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Cognitive ability</topic><topic>Computer science</topic><topic>Cross-Sectional Studies</topic><topic>Disease control</topic><topic>Female</topic><topic>Foam</topic><topic>Foams</topic><topic>Geriatrics</topic><topic>Health risks</topic><topic>Humans</topic><topic>Infection control</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Mutation</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Parkinson Disease - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maetzler, Walter</au><au>Mancini, Martina</au><au>Liepelt-Scarfone, Inga</au><au>Müller, Katharina</au><au>Becker, Clemens</au><au>van Lummel, Rob C</au><au>Ainsworth, Erik</au><au>Hobert, Markus</au><au>Streffer, Johannes</au><au>Berg, Daniela</au><au>Chiari, Lorenzo</au><au>Duda, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired trunk stability in individuals at high risk for Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-03-23</date><risdate>2012</risdate><volume>7</volume><issue>3</issue><spage>e32240</spage><epage>e32240</epage><pages>e32240-e32240</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making it tempting to speculate that changes in sway performance may even occur at a prodromal stage, and may have the potential to serve as a prodromal marker for the disease.
Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.
Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22457713</pmid><doi>10.1371/journal.pone.0032240</doi><tpages>e32240</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accelerometers Alzheimer's disease Alzheimers disease Balance Biofeedback Biology Biomarkers Biomechanics Brain research Case-Control Studies Cognitive ability Computer science Cross-Sectional Studies Disease control Female Foam Foams Geriatrics Health risks Humans Infection control Male Medical treatment Medicine Middle Aged Movement disorders Mutation Neurodegenerative diseases Neurology Parkinson Disease - physiopathology Parkinson's disease Parkinsons disease Posture R&D Research & development Risk Risk Factors Smoothness Spine Stability Torso - physiopathology |
| title | Impaired trunk stability in individuals at high risk for Parkinson's disease |
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