Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of glucose and lipid metabolism and therefore an important pharmacological target to combat metabolic diseases. Since the currently used full PPARγ agonists display serious side effects, identification of novel ligands, part...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61755
Hauptverfasser:	Atanasov, Atanas G, Blunder, Martina, Fakhrudin, Nanang, Liu, Xin, Noha, Stefan M, Malainer, Clemens, Kramer, Matthias P, Cocic, Amina, Kunert, Olaf, Schinkovitz, Andreas, Heiss, Elke H, Schuster, Daniela, Dirsch, Verena M, Bauer, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Activation Adipocytes Adipogenesis Animals Apiaceae Apiaceae - chemistry Binding Sites Biochemistry Biology Cell culture Chinese medicine Deoxyglucose - metabolism Dichloromethane Diet Dietary supplements Diynes - chemistry Diynes - isolation & purification Diynes - pharmacology Docking Fatty Alcohols - chemistry Fatty Alcohols - isolation & purification Fatty Alcohols - pharmacology Food Fractionation Genes, Reporter Genomics Glucose Glucose metabolism HEK293 Cells Herbal medicine Humans Hydrogen Hydrogen bonding Hydrogen bonds Hydrophobicity Identification Inflammation Insulin Life Sciences Ligands Lipid metabolism Lipids Luciferase Luciferases - biosynthesis Luciferases - genetics Medicinal plants Medicine Metabolic disorders Metabolism Metabolites Mice Molecular Docking Simulation Pharmaceutical sciences Pharmacology Pharmacy Plant extracts Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plasmids Polyacetylene Polyacetylenes - chemistry Polyacetylenes - isolation & purification Polyacetylenes - pharmacology PPAR gamma - agonists PPAR gamma - chemistry PPAR gamma - metabolism Protein Binding Side effects Traditional Chinese medicine Transcriptional Activation - drug effects Type 2 diabetes
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