SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function

Significant insight into the signaling pathways leading to activation of the Rel transcription factor family, collectively termed NF-κB, has been gained. Less well understood is how subsets of NF-κB-dependent genes are regulated in a signal specific manner. The SIMPL protein (signaling molecule that...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61123-e61123
Hauptverfasser:	Zhao, Weina, Breese, Erin, Bowers, Allison, Hoggatt, Jonathan, Pelus, Louis M, Broxmeyer, Hal E, Goebl, Mark, Harrington, Maureen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biology Carrier Proteins - physiology Cell cycle Complex formation Cytokines Fibroblasts Gene expression Gene Expression Regulation Genes Genomics HEK293 Cells Hematopoiesis Hematopoietic Stem Cells Humans Immune response Immune system Immunology Intracellular Signaling Peptides and Proteins Kinases Mammals Mass spectrometry Mass spectroscopy Mediator Complex Subunit 1 - metabolism Medical prognosis Medicine Mice Molecular biology Multiprotein Complexes - metabolism Necrosis NF-κB protein Oligonucleotide Array Sequence Analysis Progenitor cells Promoter Regions, Genetic Protein Transport Proteins Signaling Steady state Stem cells Transcription activation Transcription Factor RelA - metabolism Transcription factors Transcriptome Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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