Knockdown of Ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition

Transitional cell carcinoma (TCC) of the urinary bladder is the most common cancer of the urinary tract. Most of the TCC cases are of the superficial type and are treated with transurethral resection (TUR). However, the recurrence rate is high and the current treatments have the drawback of inducing...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48567
Hauptverfasser:	Pichu, Sivakamasundari, Krishnamoorthy, Swapna, Shishkov, Andrei, Zhang, Bi, McCue, Peter, Ponnappa, Biddanda C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Biology Bladder Bladder cancer Cancer Cancer cells Cancer therapies Cancer treatment Carcinoma, Transitional Cell - genetics Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemistry Chemotherapy Clinical trials Curcumin Curcumin - pharmacology Cyclin-dependent kinases Cystitis Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Drug Resistance, Neoplasm - genetics Drugs Gene Expression Regulation, Neoplastic Genes Health aspects Humans Ki-67 Antigen - genetics Kinases Medicine mRNA Nucleoli p53 Protein Pathology Proteins Rats Ribonuclease III - metabolism Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - drug effects siRNA Substrates Toxicity Transitional cell carcinoma Tumor proteins Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary tract
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