Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Beta amyloid peptides (A[beta]) play a key role in the pathogenesis of Alzheimer disease (AD). Presenilins (PS) function as the catalytic subunits of [gamma]-secretase, the enzyme that releases A[beta] from ectodomain cleaved amyloid precursor protein (APP) by intramembrane proteolysis. Familial Alz...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48551
Hauptverfasser:	Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Amino acids Amyloid beta-protein Amyloid precursor protein Biology Catalysis Catalytic subunits Chimeras Enzymes Flavin-adenine dinucleotide Fusion protein Gene therapy Genetic aspects Geriatrics Medicine Methods Molecular interactions Mutagenesis Mutation N-Terminus Neurodegenerative diseases Neurosciences Pathogenesis Peptides Precursors Presenilin 1 Protein C Proteins Proteolysis Proteomics Psychiatry Quarks Relative abundance Secretase Stem cells β-Amyloid
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