Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb

Recent studies have led to the exciting idea that adult-born neurons in the olfactory bulb (OB) may be critical for complex forms of olfactory behavior in mice. However, signaling mechanisms regulating adult OB neurogenesis are not well defined. We recently reported that extracellular signal-regulat...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61948
Hauptverfasser:	Li, Tan, Pan, Yung-Wei, Wang, Wenbin, Abel, Glen, Zou, Junhui, Xu, Lihong, Storm, Daniel R, Xia, Zhengui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biology Brain Cell culture Cell Cycle Cell Movement Cell Survival Cells (biology) Cells, Cultured Cellular biology Cerebral Ventricles - cytology Cerebral Ventricles - enzymology Clonal deletion Differentiation Extracellular signal-regulated kinase Gene deletion Gene Knockout Techniques Health sciences Kinases MAP kinase Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinase 7 - deficiency Mitogen-Activated Protein Kinase 7 - genetics Nervous system Neural stem cells Neural Stem Cells - physiology Neuroblasts Neurogenesis Neurons Neurons - physiology Occupational health Olfactory bulb Olfactory Bulb - cytology Primary Cell Culture Proteins Rodents Signaling Stem cells Subventricular zone Survival Toxicology
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