Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β

Although chronic 17β-estradiol (E2) has been shown to be a cognition-preserving and neuroprotective agent in animal brain injury models, concern regarding its safety was raised by the failed translation of this phenomenon to the clinic. Previously, we demonstrated that a single bolus of E2 48 hr pri...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60716
Hauptverfasser:	Raval, Ami P, Borges-Garcia, Raquel, Javier Moreno, William, Perez-Pinzon, Miguel A, Bramlett, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Activation AMP Animal cognition Animal models Animals Apoptosis Biology Brain Brain - drug effects Brain - metabolism Brain - pathology Brain damage Brain injury Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - prevention & control Brain research CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - pathology Cell survival Cognition Cognitive ability Cyclic AMP Response Element-Binding Protein - metabolism Cytochrome Drug dosages Endocrinology Estradiol - pharmacology Estradiol - therapeutic use Estrogen Receptor beta - agonists Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Female Females Gene expression Gene Silencing - drug effects Glucose - deficiency Head injuries Hippocampus Hormone replacement therapy Injury prevention Ischemia Laboratory animals Ligands Medicine Memory Memory - drug effects Menopause Models, Biological Neurology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Ovariectomy Oxygen - pharmacology Phosphorylation Phosphorylation - drug effects Proteins Rats Rats, Sprague-Dawley Rodents Sex hormones Spatial discrimination learning Spatial memory Womens health
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