Deciphering the preference and predicting the viability of circular permutations in proteins

Circular permutation (CP) refers to situations in which the termini of a protein are relocated to other positions in the structure. CP occurs naturally and has been artificially created to study protein function, stability and folding. Recently CP is increasingly applied to engineer enzyme structure...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31791-e31791
Hauptverfasser:	Lo, Wei-Cheng, Dai, Tian, Liu, Yen-Yi, Wang, Li-Fen, Hwang, Jenn-Kang, Lyu, Ping-Chiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino Acid Sequence Analysis Artificial intelligence Artificial neural networks Back propagation Biochemistry Bioinformatics Biology Biotechnology Bonding strength Chemical bonds Coiling Coils Computer Simulation Datasets Dihydrofolate reductase Enzymes Forest management Helices Hydrogen Hydrogen bonding Hydrogen bonds Hydrophobicity Learning algorithms Ligands Machine learning Models, Molecular Molecular biology Molecular dynamics Mutagenesis Neural networks Permutations Predictions Protein Engineering Protein folding Proteins Proteins - chemistry Reductase Researchers Residues Simulation Software packages Statistical methods Statistical tests Structural stability Structure-function relationships Support Vector Machine Viability
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