Roles of MAPK and spindle assembly checkpoint in spontaneous activation and MIII arrest of rat oocytes

Rat oocytes are well known to undergo spontaneous activation (SA) after leaving the oviduct, but the SA is abortive with oocytes being arrested in metaphase III (MIII) instead of forming pronuclei. This study was designed to investigate the mechanism causing SA and MIII arrest. Whereas few oocytes c...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e32044-e32044
Hauptverfasser:	Cui, Wei, Zhang, Jie, Lian, Hua-Yu, Wang, Hui-Li, Miao, De-Qiang, Zhang, Chuan-Xin, Luo, Ming-Jiu, Tan, Jing-He
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Assembly Biology Calcium Calcium ions Cell cycle Cell Nucleus - metabolism Chorionic Gonadotropin - metabolism Chorionic gonadotropins Chromosomes Cloning Deactivation Defects Disintegration Disturbance Eggs Female Hypotheses Inactivation Kinases M Phase Cell Cycle Checkpoints Mammals MAP kinase MAP Kinase Signaling System Maturation-promoting factor Maturation-Promoting Factor - metabolism Metaphase Microscopy, Confocal - methods Microtubules Mitogens Oocytes Oocytes - cytology Oviduct Phosphorylation Protein kinase Protein kinases Protein-Serine-Threonine Kinases - metabolism Proteins Rats Rats, Sprague-Dawley Rodents Smad2 Protein - metabolism Spindle Apparatus - metabolism Stem cells Studies Time Factors
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