Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase

Chromosomal translocations in tumors frequently produce fusion genes coding for chimeric proteins with a key role in oncogenesis. Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of the chimeric protein remains uncharacterized....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e32451-e32451
Hauptverfasser:	Cuesta-Domínguez, Álvaro, Ortega, Mara, Ormazábal, Cristina, Santos-Roncero, Matilde, Galán-Díez, Marta, Steegmann, Juan Luis, Figuera, Ángela, Arranz, Eva, Vizmanos, José Luis, Bueren, Juan A, Río, Paula, Fernández-Ruiz, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl protein Acute lymphoblastic leukemia Acute myeloid leukemia Analysis Animals Apoptosis Autografts B cells Bcl-x protein bcl-X Protein - metabolism BCR protein BCR-ABL protein Biology Blood Bone marrow Cell activation Cell Line Cell proliferation Cell survival Cells (biology) Chromosome translocations Chromosomes Cytokines Cytoplasm Deregulation Female Fluorescence Fluorescence in situ hybridization Fusion protein Gene expression Gene therapy Genes Glycoproteins HEK293 Cells Hematology Hemopoiesis Humans Inhibitors Interleukin 3 Janus kinase 2 Janus Kinase 2 - metabolism Kinases Leukemia Lymphatic leukemia Lymphoma Male Medical treatment Medicine Mice Mice, Nude Middle Aged Minimal residual disease Molecular biology Molecular modelling Myeloid leukemia Nuclei (cytology) Oligomerization Oligomers Oncogene Proteins, Fusion - metabolism Phenols (Class of compounds) Phosphorylation Polymerase chain reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Progenitor cells Protein Structure, Tertiary Proteins Proto-Oncogene Proteins c-bcr - metabolism Real-Time Polymerase Chain Reaction - methods Reverse Transcriptase Polymerase Chain Reaction - methods Stem cells Survival Transgenic animals Translocation Transplantation Tumors Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!