Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition

Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth cell function and intestinal microbial composition...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e32403-e32403
Hauptverfasser:	Gulati, Ajay S, Shanahan, Michael T, Arthur, Janelle C, Grossniklaus, Emily, von Furstenberg, Richard J, Kreuk, Lieselotte, Henning, Susan J, Jobin, Christian, Sartor, R Balfour
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Defensins - metabolism Analysis Animals Antiinfectives and antibacterials Antimicrobial activity Antimicrobial Cationic Peptides - chemistry Bacteria Biology Colonization Colorectal cancer Crohn's disease Crohns disease Cytokines Cytometry Defensins Dendritic cells Disease susceptibility E coli Epithelial Cells - cytology Escherichia coli - metabolism Flow cytometry Flow Cytometry - methods Gastric Mucosa - metabolism Gastroenterology Gel electrophoresis Genetic aspects Genotype Genotype & phenotype Genotypes Germfree Gnotobiotics Hepatology Homeostasis House mouse Immune system Immunohistochemistry - methods Inbreeding Inflammation Inflammatory bowel disease Influence Intestinal microflora Intestine Intestines - microbiology Lactobacillus Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Medicine Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Microorganisms Paneth cells Paneth Cells - cytology Peptides Physiology Polymerase chain reaction Polymorphism Polymorphism, Restriction Fragment Length Restriction fragment length polymorphism Reverse Transcriptase Polymerase Chain Reaction - methods Rodents Signal Transduction Small intestine Stem cells Stomach - microbiology Strains (organisms) Urea
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