Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease

The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to underlie AD pathophysiology, however, no compr...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e32737
Hauptverfasser:	Trushina, Eugenia, Nemutlu, Emirhan, Zhang, Song, Christensen, Trace, Camp, Jon, Mesa, Janny, Siddiqui, Ammar, Tamura, Yasushi, Sesaki, Hiromi, Wengenack, Thomas M, Dzeja, Petras P, Poduslo, Joseph F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Advertising executives Age Alterations Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Amino acids Amyloid - genetics Amyloid beta-protein Amyloid precursor protein Animal models Animals Biochemistry Biology Biomarkers Biomarkers - metabolism Brain Brain - metabolism Carbohydrates Cell death Chromatography Cytology Disease Models, Animal Disease Progression Dynamics Embryos Energy metabolism Energy transfer Excitotoxicity Gender aspects Genetic aspects Hippocampus - metabolism Humans Identification Krebs cycle Mass spectrometry Medicine Memory Metabolic pathways Metabolism Metabolites Metabolomics Metabolomics - methods Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria Mitochondria - metabolism Molecular biology Molecular modelling Morphology Motility Musculoskeletal system Mutation Neurodegenerative diseases Neurology Neurons Neurons - metabolism Pharmacology Physiological aspects Presenilin 1 Presenilin-1 - genetics Profiling Rodents Saccharomyces cerevisiae Scientific imaging Sex differences Signatures Stress Stresses Time Factors Transgenic mice Tricarboxylic acid cycle
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