Cord blood stem cells inhibit epidermal growth factor receptor translocation to mitochondria in glioblastoma

Overexpression of EGFR is one of the most frequently diagnosed genetic aberrations of glioblastoma multiforme (GBM). EGFR signaling is involved in diverse cellular functions and is dependent on the type of preferred receptor complexes. EGFR translocation to mitochondria has been reported recently in...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31884-e31884
Hauptverfasser:	Dasari, Venkata Ramesh, Velpula, Kiran Kumar, Alapati, Kiranmai, Gujrati, Meena, Tsung, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Analysis Animals Apoptosis Biology Blood Brain cancer Brain tumors Cancer therapies Clinical trials Colorectal cancer Cord blood CSK Tyrosine-Protein Kinase Departments Epidermal growth factor Epidermal growth factor receptors Epidermal growth factors ErbB Receptors - metabolism Fetal Blood - cytology Focal Adhesion Kinase 1 - metabolism Glioblastoma Glioblastoma - metabolism Glioblastoma multiforme Glioblastomas Glioma Glioma cells Hematopoietic stem cells Humans Immunohistochemistry Kinases Ligands Localization Lung cancer Medicine Metastasis Mice Mitochondria Mitochondria - metabolism Pancreatic cancer Patients Pharmacology Phosphorylation Protein Transport Protein-Tyrosine Kinases - metabolism Proteins Rodents Signal Transduction Src protein src-Family Kinases Stem cell transplantation Stem cells Stem Cells - physiology Translocation Umbilical cord Western blotting Xenografts
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