Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection

We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as possible target antigens. Detailed analysis of the expression of MICA, MICB, ULBP-1, -2, and -3 in fourteen ESFT cell lines revealed consi...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31210-e31210
Hauptverfasser:	Lehner, Manfred, Götz, Gabriel, Proff, Julia, Schaft, Niels, Dörrie, Jan, Full, Florian, Ensser, Armin, Muller, Yves A, Cerwenka, Adelheid, Abken, Hinrich, Parolini, Ornella, Ambros, Peter F, Kovar, Heinrich, Holter, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anchoring Antigens Apoptosis B cells Biology Blotting, Western C-Terminus Cancer therapies CD28 antigen Cell death Cell Proliferation Cell recognition Cell surface Children & youth Cytotoxicity Dermatology Enzyme-Linked Immunosorbent Assay Ewing's sarcoma Ewings sarcoma Flow Cytometry Gene expression Gene transfer Humans Immunotherapy Laboratories Ligands Localization Lymphocyte Activation Lymphocytes Lymphocytes T Major histocompatibility complex Medical prognosis Medical research Medicine Melanoma Messenger RNA Modulation mRNA NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reengineering Ribonucleic acid RNA RNA, Messenger - administration & dosage Sarcoma Sarcoma, Ewing - immunology Sarcoma, Ewing - therapy Signal transduction T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - transplantation Target recognition Transfection Tumor Cells, Cultured Tumors Virology
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