Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin

The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation. Endotoxin and C5a activate the enzyme sphingosine kinase (Sphk) 1 to generate the signaling lipid sphingosine-1-phosphate (S1P), a critical r...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e30742
Hauptverfasser:	Bachmaier, Kurt, Guzman, Edgar, Kawamura, Takeshi, Gao, Xiaopei, Malik, Asrar B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylatoxins - pharmacology Animals Apoptosis Biology Bone Marrow - drug effects Bone Marrow - metabolism Cell activation Cell surface Chemokines Chromatography Comparative analysis Complement component C5a Cytokines Cytokines - metabolism Drug dosages Endotoxins Enzyme-Linked Immunosorbent Assay Enzymes Flow Cytometry Genotype & phenotype Homeostasis Inflammation Inflammatory response Injuries Kinases Leukocyte migration Leukocytes (neutrophilic) Lipopolysaccharides Lipopolysaccharides - toxicity Lung diseases Lungs Lysophospholipids - pharmacology Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mass spectrometry Mediation Medicine Mice Mice, Inbred C57BL Mice, Knockout Neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Phagocytes Pharmacology Phosphates Phosphorylation - drug effects Phosphotransferases (Alcohol Group Acceptor) - physiology Pneumonia - chemically induced Pneumonia - metabolism Pneumonia - pathology Receptor, Anaphylatoxin C5a - metabolism Receptors Receptors, Chemokine - metabolism Rodents Scientific imaging Sepsis Sepsis - chemically induced Sepsis - metabolism Sepsis - pathology Signal Transduction - drug effects Sphingosine Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine 1-phosphate Sphingosine kinase Tumor necrosis factor-TNF
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