Morphine suppresses IFN signaling pathway and enhances AIDS virus infection

Opioids exert a profound influence on immunomodulation and enhance HIV infection and replication. However, the mechanism(s) of their action remains to be determined. We thus investigated the impact of morphine on the intracellular innate antiviral immunity. Seven-day-cultured macrophages were infect...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31167
Hauptverfasser:	Wang, Yizhong, Wang, Xu, Ye, Li, Li, Jieliang, Song, Li, Fulambarkar, Nilija, Ho, Wenzhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Biology Cells, Cultured Disease susceptibility Gene expression Health aspects HIV HIV infections HIV Infections - chemically induced HIV tests Human immunodeficiency virus Humans Immunity Immunity, Innate - drug effects Immunofluorescence Immunomodulation Infection Infections Interferon Interferon regulatory factor 7 Interferons - antagonists & inhibitors Interferons - metabolism Intracellular Intracellular signalling Kinases Macrophages Macrophages - virology Medicine Monocytes Morphine Morphine - pharmacology Narcotics Opioids Polymerase chain reaction Regulators Replication RNA Signal transduction Signal Transduction - drug effects Simian Immunodeficiency Virus Stat1 protein Viral infections Virus replication Virus Replication - drug effects Viruses
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