Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease and major risk factor for severe respiratory syncytial virus (RSV) infection among preterm infants. The Toll-like receptor 4 (TLR4) is involved in oxidative injury responses in the lungs. Two non-synonymous single nucleotide polymorph...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31351-e31351
Hauptverfasser:	Lavoie, Pascal M, Ladd, Mihoko, Hirschfeld, Aaron F, Huusko, Johanna, Mahlman, Mari, Speert, David P, Hallman, Mikko, Lacaze-Masmonteil, Thierry, Turvey, Stuart E
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Apoptosis Babies Biology Birth weight Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - genetics Case-Control Studies Children Children & youth Disease Diseases Dysplasia Female Genes Genetic aspects Genetic Predisposition to Disease Genomics Genotype Genotypes Gestational age Health risks Heterozygote Humans Hyperoxia Immunology Incidence Infant Infant, Newborn Infant, Premature Infants Infections Lung diseases Lungs Medicine Menstruation Minority & ethnic groups Mutation, Missense Newborn babies Pediatrics Polymorphism, Genetic Population Population studies Pregnancy Premature birth Premature infants Respiratory syncytial virus Risk factors Sepsis Siblings Single nucleotide polymorphisms Single-nucleotide polymorphism TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Viruses
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