P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1

Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. To assess whet...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43057-e43057
Hauptverfasser:	Backlund, Lena, Lavebratt, Catharina, Frisén, Louise, Nikamo, Pernilla, Hukic Sudic, Dzana, Träskman-Bendz, Lil, Landén, Mikael, Edman, Gunnar, Vawter, Marquis P, Ösby, Urban, Schalling, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Analysis Biology Bipolar disorder Bipolar Disorder - genetics Bipolar Disorder - metabolism Blood Child circadian clock Circadian rhythm Clinical Medicine Cohort Studies Consent Cycles Cycling Deprivation disequilibrium Diurnal Female gene Gene expression Gene Expression Regulation Genetic aspects Genetic Predisposition to Disease Genetic variation Genetics Genomics Haplotypes Health care facilities Hospitals Humans Kinases Klinisk medicin Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology linkage Male Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine Mental depression Middle Aged Mitochondrial DNA Models, Genetic mood disorders netics Neurosciences neurotrophic factor bdnf Neurovetenskaper Oligonucleotide Array Sequence Analysis p1063 p295 p2x receptors p374 p847 Patients Peripheral blood mononuclear cells phase-shifts Physiological aspects Polymorphism, Single Nucleotide protein-kinase Psychiatry Psychological aspects Psykiatri Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - physiology Review boards Ribonucleic acid Risk factors RNA Single-nucleotide polymorphism single-nucleotide polymorphisms Sleep Sleep and wakefulness Sleep Deprivation Studies Surgery Sweden synthase kinase-3 v141b v150b v153b
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