Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension

Acute ocular hypertension (AOH) is a condition found in acute glaucoma. The purpose of this study is to investigate the protective effect of Lycium barbarum polysaccharides (LBP) and its protective mechanisms in the AOH insult. LBP has been shown to exhibit neuroprotective effect in the chronic ocul...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e45469
Hauptverfasser:	Mi, Xue-Song, Feng, Qian, Lo, Amy Cheuk Yin, Chang, Raymond Chuen-Chung, Lin, Bin, Chung, Sookja Kim, So, Kwok-Fai
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Alzheimers disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animal cognition Animals Biology Blood Blood vessels Blood-Retinal Barrier - drug effects Blood-Retinal Barrier - metabolism Blood-Retinal Barrier - pathology Brain research Care and treatment Chinese medicine Damage prevention Degeneration Diabetes Disease Models, Animal Down-Regulation - drug effects Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Endothelin 1 Endothelin-1 - genetics Endothelin-1 - metabolism Eye Eye injuries Eye manifestations Gene Expression - drug effects Glaucoma Goji berries Health aspects Hypertension Immunoglobulin G Immunoglobulin G - metabolism Injury prevention Ischemia Laboratory animals Leakage Lycium barbarum Male Medicine Mice Mice, Inbred C57BL Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Degeneration - prevention & control Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Ocular Hypertension - genetics Ocular Hypertension - metabolism Ocular Hypertension - pathology Ocular Hypertension - prevention & control Pathogenesis Polysaccharides Proteins Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Retina Retinal ganglion cells Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Retinal Vessels - drug effects Retinal Vessels - metabolism Retinal Vessels - pathology Retinopathy Rodents Saccharides Science Signal Transduction - drug effects Signaling Studies Systematic review Therapeutic applications Thinning Tight junctions Tight Junctions - drug effects Tight Junctions - metabolism Tight Junctions - pathology
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