Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma

It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear. In the present study, the methods of Western blotting and i...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60516
Hauptverfasser:	Lin, Huan-Xin, Qiu, Hui-Juan, Zeng, Fei, Rao, Hui-Lan, Yang, Guo-Fen, Kung, Hsiang-Fu, Zhu, Xiao-Feng, Zeng, Yi-Xin, Cai, Mu-Yan, Xie, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis Regulatory Proteins - metabolism Area Under Curve Autophagy Bcl-x protein bcl-X Protein - metabolism Beclin-1 Cancer Cancer therapies Carcinoma - metabolism Carcinoma - mortality Cell death Correlation Cystadenoma - metabolism Cystadenoma - mortality Esophagus Ethics Female Gene expression Genetic aspects Gynecology Hospitals Humans Immunohistochemistry Kaplan-Meier Estimate Laboratories Liver cancer Lymphoma Medical prognosis Medicine Membrane Proteins - metabolism Middle Aged Multivariate Analysis Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovaries Paraffin Pathology Patients Phagocytosis Prognosis Proportional Hazards Models Proteins Quality ROC Curve Rodents Survival Tissue Array Analysis Tissues Tumors Western blotting
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