Effects of pre-experience of social exclusion on hypothalamus-pituitary-adrenal axis and catecholaminergic responsiveness to public speaking stress
Being socially excluded is associated with a variety of psychological changes and with an increased risk of disease. Today, the immediate physiological consequences of being socially excluded are not well understood. In two recent studies employing a standardized exclusion paradigm (Cyberball) we fo...
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| description | Being socially excluded is associated with a variety of psychological changes and with an increased risk of disease. Today, the immediate physiological consequences of being socially excluded are not well understood. In two recent studies employing a standardized exclusion paradigm (Cyberball) we found social exclusion in this virtual game did not alter cortisol secretion directly. However, exclusion pre-experience suppresses the normal cortisol response to public speaking stress in women. The present study aims to replicate our previous finding and further elucidate it by analyzing for the first time whether this alteration of cortisol-responsiveness is associated to ACTH and whether the catecholaminergic system is affected as well.
Women were randomly assigned to Cyberball-induced exclusion (SE, n = 22) or inclusion (SI, n = 21), respectively. Immediately afterwards they were subjected to public speaking stress. Salivary cortisol, plasma ACTH, catecholamines and estradiol were assessed as were psychological distress and mood.
Cyberball exclusion led to a highly significant immediate increase in negative affect in excluded women. After public speaking negative affect in included women increased as well and groups no longer differed. We replicate our previous finding of cortisol non-responsiveness to public speaking stress after exclusion pre-experience and find this effect to be significantly correlated with ACTH alterations. No such effects are observed for catecholamines.
We replicated our previous study result of a suppressed cortisol stress response after a short exclusion experience via Cyberball, thereby underlining the profound effects of social exclusion on a subsequent cortisol stress response. This further demonstrates that these alterations are associated with ACTH. Lack of effects on catecholamines is discussed in view of the tend-and-befriend hypothesis but also from a methodological perspective. |
| doi_str_mv | 10.1371/journal.pone.0060433 |
| format | Article |
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Women were randomly assigned to Cyberball-induced exclusion (SE, n = 22) or inclusion (SI, n = 21), respectively. Immediately afterwards they were subjected to public speaking stress. Salivary cortisol, plasma ACTH, catecholamines and estradiol were assessed as were psychological distress and mood.
Cyberball exclusion led to a highly significant immediate increase in negative affect in excluded women. After public speaking negative affect in included women increased as well and groups no longer differed. We replicate our previous finding of cortisol non-responsiveness to public speaking stress after exclusion pre-experience and find this effect to be significantly correlated with ACTH alterations. No such effects are observed for catecholamines.
We replicated our previous study result of a suppressed cortisol stress response after a short exclusion experience via Cyberball, thereby underlining the profound effects of social exclusion on a subsequent cortisol stress response. This further demonstrates that these alterations are associated with ACTH. Lack of effects on catecholamines is discussed in view of the tend-and-befriend hypothesis but also from a methodological perspective.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0060433</identifier><identifier>PMID: 23573255</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>17β-Estradiol ; Adolescent ; Adrenocorticotropic hormone ; Adrenocorticotropic Hormone - blood ; Adult ; Affect ; Biology ; Catecholamine metabolism ; Catecholamines ; Cortisol ; Effects ; Emotions ; Epinephrine - blood ; Estradiol - blood ; Female ; Gender differences ; Health psychology ; Health risks ; Hormones ; Humans ; Hydrocortisone - metabolism ; Hypothalamo-Hypophyseal System - physiology ; Hypothalamus ; Medicine ; Mens health ; Mood ; Norepinephrine - blood ; Observations ; Pain ; Physiology ; Pituitary ; Pituitary-Adrenal System - physiology ; Psychobiology ; Psychological aspects ; Psychological distress ; Public speaking ; Risk assessment ; Saliva - metabolism ; Secretion ; Self esteem ; Sex hormones ; Social and Behavioral Sciences ; Social aspects ; Social exclusion ; Social Isolation - psychology ; Social support ; Speech - physiology ; Stress ; Stress (Psychology) ; Stress response ; Stress, Psychological - blood ; Stresses ; Studies ; Women ; Womens health ; Young Adult</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e60433-e60433</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Weik et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Weik et al 2013 Weik et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c725a03f2c7ff27ce6951c7e102a78b456fe426e3c83caa26bca639ec536e60e3</citedby><cites>FETCH-LOGICAL-c692t-c725a03f2c7ff27ce6951c7e102a78b456fe426e3c83caa26bca639ec536e60e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616100/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616100/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27321,27901,27902,33751,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23573255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weik, Ulrike</creatorcontrib><creatorcontrib>Kuepper, Yvonne</creatorcontrib><creatorcontrib>Hennig, Juergen</creatorcontrib><creatorcontrib>Deinzer, Renate</creatorcontrib><title>Effects of pre-experience of social exclusion on hypothalamus-pituitary-adrenal axis and catecholaminergic responsiveness to public speaking stress</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Being socially excluded is associated with a variety of psychological changes and with an increased risk of disease. Today, the immediate physiological consequences of being socially excluded are not well understood. In two recent studies employing a standardized exclusion paradigm (Cyberball) we found social exclusion in this virtual game did not alter cortisol secretion directly. However, exclusion pre-experience suppresses the normal cortisol response to public speaking stress in women. The present study aims to replicate our previous finding and further elucidate it by analyzing for the first time whether this alteration of cortisol-responsiveness is associated to ACTH and whether the catecholaminergic system is affected as well.
Women were randomly assigned to Cyberball-induced exclusion (SE, n = 22) or inclusion (SI, n = 21), respectively. Immediately afterwards they were subjected to public speaking stress. Salivary cortisol, plasma ACTH, catecholamines and estradiol were assessed as were psychological distress and mood.
Cyberball exclusion led to a highly significant immediate increase in negative affect in excluded women. After public speaking negative affect in included women increased as well and groups no longer differed. We replicate our previous finding of cortisol non-responsiveness to public speaking stress after exclusion pre-experience and find this effect to be significantly correlated with ACTH alterations. No such effects are observed for catecholamines.
We replicated our previous study result of a suppressed cortisol stress response after a short exclusion experience via Cyberball, thereby underlining the profound effects of social exclusion on a subsequent cortisol stress response. This further demonstrates that these alterations are associated with ACTH. Lack of effects on catecholamines is discussed in view of the tend-and-befriend hypothesis but also from a methodological perspective.</description><subject>17β-Estradiol</subject><subject>Adolescent</subject><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Affect</subject><subject>Biology</subject><subject>Catecholamine metabolism</subject><subject>Catecholamines</subject><subject>Cortisol</subject><subject>Effects</subject><subject>Emotions</subject><subject>Epinephrine - blood</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Gender differences</subject><subject>Health psychology</subject><subject>Health risks</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Hypothalamus</subject><subject>Medicine</subject><subject>Mens health</subject><subject>Mood</subject><subject>Norepinephrine - 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blood</topic><topic>Adult</topic><topic>Affect</topic><topic>Biology</topic><topic>Catecholamine metabolism</topic><topic>Catecholamines</topic><topic>Cortisol</topic><topic>Effects</topic><topic>Emotions</topic><topic>Epinephrine - blood</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Gender differences</topic><topic>Health psychology</topic><topic>Health risks</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Hypothalamus</topic><topic>Medicine</topic><topic>Mens health</topic><topic>Mood</topic><topic>Norepinephrine - blood</topic><topic>Observations</topic><topic>Pain</topic><topic>Physiology</topic><topic>Pituitary</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Psychobiology</topic><topic>Psychological aspects</topic><topic>Psychological distress</topic><topic>Public speaking</topic><topic>Risk assessment</topic><topic>Saliva - metabolism</topic><topic>Secretion</topic><topic>Self esteem</topic><topic>Sex hormones</topic><topic>Social and Behavioral Sciences</topic><topic>Social aspects</topic><topic>Social exclusion</topic><topic>Social Isolation - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weik, Ulrike</au><au>Kuepper, Yvonne</au><au>Hennig, Juergen</au><au>Deinzer, Renate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of pre-experience of social exclusion on hypothalamus-pituitary-adrenal axis and catecholaminergic responsiveness to public speaking stress</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-03</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e60433</spage><epage>e60433</epage><pages>e60433-e60433</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Being socially excluded is associated with a variety of psychological changes and with an increased risk of disease. Today, the immediate physiological consequences of being socially excluded are not well understood. In two recent studies employing a standardized exclusion paradigm (Cyberball) we found social exclusion in this virtual game did not alter cortisol secretion directly. However, exclusion pre-experience suppresses the normal cortisol response to public speaking stress in women. The present study aims to replicate our previous finding and further elucidate it by analyzing for the first time whether this alteration of cortisol-responsiveness is associated to ACTH and whether the catecholaminergic system is affected as well.
Women were randomly assigned to Cyberball-induced exclusion (SE, n = 22) or inclusion (SI, n = 21), respectively. Immediately afterwards they were subjected to public speaking stress. Salivary cortisol, plasma ACTH, catecholamines and estradiol were assessed as were psychological distress and mood.
Cyberball exclusion led to a highly significant immediate increase in negative affect in excluded women. After public speaking negative affect in included women increased as well and groups no longer differed. We replicate our previous finding of cortisol non-responsiveness to public speaking stress after exclusion pre-experience and find this effect to be significantly correlated with ACTH alterations. No such effects are observed for catecholamines.
We replicated our previous study result of a suppressed cortisol stress response after a short exclusion experience via Cyberball, thereby underlining the profound effects of social exclusion on a subsequent cortisol stress response. This further demonstrates that these alterations are associated with ACTH. Lack of effects on catecholamines is discussed in view of the tend-and-befriend hypothesis but also from a methodological perspective.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23573255</pmid><doi>10.1371/journal.pone.0060433</doi><tpages>e60433</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Sociological Abstracts; Public Library of Science (PLoS) |
| subjects | 17β-Estradiol Adolescent Adrenocorticotropic hormone Adrenocorticotropic Hormone - blood Adult Affect Biology Catecholamine metabolism Catecholamines Cortisol Effects Emotions Epinephrine - blood Estradiol - blood Female Gender differences Health psychology Health risks Hormones Humans Hydrocortisone - metabolism Hypothalamo-Hypophyseal System - physiology Hypothalamus Medicine Mens health Mood Norepinephrine - blood Observations Pain Physiology Pituitary Pituitary-Adrenal System - physiology Psychobiology Psychological aspects Psychological distress Public speaking Risk assessment Saliva - metabolism Secretion Self esteem Sex hormones Social and Behavioral Sciences Social aspects Social exclusion Social Isolation - psychology Social support Speech - physiology Stress Stress (Psychology) Stress response Stress, Psychological - blood Stresses Studies Women Womens health Young Adult |
| title | Effects of pre-experience of social exclusion on hypothalamus-pituitary-adrenal axis and catecholaminergic responsiveness to public speaking stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T17%3A15%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20pre-experience%20of%20social%20exclusion%20on%20hypothalamus-pituitary-adrenal%20axis%20and%20catecholaminergic%20responsiveness%20to%20public%20speaking%20stress&rft.jtitle=PloS%20one&rft.au=Weik,%20Ulrike&rft.date=2013-04-03&rft.volume=8&rft.issue=4&rft.spage=e60433&rft.epage=e60433&rft.pages=e60433-e60433&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0060433&rft_dat=%3Cgale_plos_%3EA478439857%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330914165&rft_id=info:pmid/23573255&rft_galeid=A478439857&rft_doaj_id=oai_doaj_org_article_047750cc2a5d4d4f9404cf1696adcad3&rfr_iscdi=true |