Variation in dietary salt intake induces coordinated dynamics of monocyte subsets and monocyte-platelet aggregates in humans: implications in end organ inflammation

Monocyte activation and tissue infiltration are quantitatively associated with high-salt intake induced target organ inflammation. We hypothesized that high-salt challenge would induce the expansion of CD14++CD16+ monocytes, one of the three monocyte subsets with a pro-inflammatory phenotype, that i...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60332
Hauptverfasser:	Zhou, Xin, Zhang, Ling, Ji, Wen-Jie, Yuan, Fei, Guo, Zhao-Zeng, Pang, Bo, Luo, Tao, Liu, Xing, Zhang, Wen-Cheng, Jiang, Tie-Min, Zhang, Zhuoli, Li, Yu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Antigens, CD - metabolism Biology Blood Blood Chemical Analysis Blood platelets Blood Platelets - immunology Blood Platelets - metabolism Blood Pressure Cardiovascular disease CD14 antigen CD16 antigen Cell activation Cell Adhesion Cell Communication - immunology Creatinine - urine Cytometry Development and progression Diet Dietary intake Excretion Expansion Flow cytometry Gene expression Gene Expression Profiling Genetic aspects Heart Heart Rate Homeostasis Humans Hypertension Hypoxia Immunity Immunophenotyping Infiltration Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Innate immunity Intervention Kidney - immunology Kidney - metabolism Kidney - pathology Kidneys Logistics Magnetic resonance Magnetic Resonance Imaging Medicine Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Monocytes - immunology Monocytes - metabolism NMR Nuclear magnetic resonance Oxidative Stress Oxygen Oxygen Consumption Physiological aspects Platelets Reactive oxygen species Reactive Oxygen Species - metabolism Renal Circulation Risk factors Salt Salts Sodium Sodium chloride Sodium Chloride, Dietary Studies Thromboembolism Urine
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