The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance

The main features of translation are similar in all organisms on this planet and one important feature of it is the way the ribosome maintain the reading frame. We have earlier characterized several bacterial mutants defective in tRNA maturation and found that some of them correct a +1 frameshift mu...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60246-e60246
Hauptverfasser:	Jäger, Gunilla, Nilsson, Kristina, Björk, Glenn R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alterations Amino Acid Sequence Anticodon Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Base Sequence Biology Codon Defects E coli Error correction Escherichia coli Frameshift Mutation Gene mutations Loci Maintenance Molecular biology Molecular Sequence Data Mutants Mutation Nucleic Acid Conformation Operon - physiology Phenotype Physiological aspects Protein Biosynthesis - physiology Proteins Reading Reading Frames Ribosomal protein S9 Ribosomal Proteins - chemistry Ribosomes - physiology RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - physiology Salmonella Salmonella Typhimurium Transfer RNA tRNA
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