Dermal mesenchymal stem cells (DMSCs) inhibit skin-homing CD8+ T cell activity, a determining factor of vitiligo patients' autologous melanocytes transplantation efficiency

We here investigated the efficiency of autologous melanocyte transplantation of 23 vitiligo patients by focusing on perilesional skin homing CD8+ T lymphocytes, and studied the potential effect of dermal mesenchymal stem cells (DMSCs) on CD8+ T cell activities in vitro. Out of 23 patients with the a...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60254-e60254
Hauptverfasser:	Zhou, Miao-ni, Zhang, Zhi-qing, Wu, Ji-long, Lin, Fu-quan, Fu, Li-fang, Wang, Sui-qan, Guan, Cui-ping, Wang, Hong-lin, Xu, Aie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Autografts Biology Bone marrow CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell culture Cell growth Cell Proliferation Cell Transplantation Chemokines Chemokines - biosynthesis Chemokines - metabolism Cytokines Cytotoxicity Dermatology Efficiency Epidermis - immunology Epidermis - metabolism Epidermis - pathology Female Gene Expression Regulation - immunology Homing Hospitals Humans Lymphocytes Lymphocytes T Male Medical research Medicine Melanocytes Melanocytes - transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Nitric oxide Patients Pigmentation Pigmentation - immunology Skin Skin - cytology Skin - immunology Skin - metabolism Skin - pathology Stem cells Studies T cells Transplantation Transplantation, Autologous Transplants & implants Vitiligo Vitiligo - immunology Vitiligo - metabolism Vitiligo - surgery
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