Enhanced human tissue microdialysis using hydroxypropyl-ß-cyclodextrin as molecular carrier

Microdialysis sampling of lipophilic molecules in human tissues is challenging because protein binding and adhesion to the membrane limit recovery. Hydroxypropyl-ß-cyclodextrin (HP-ß-CD) forms complexes with hydrophobic molecules thereby improving microdialysis recovery of lipophilic molecules in vi...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60628
Hauptverfasser:	May, Marcus, Batkai, Sandor, Zoerner, Alexander A, Tsikas, Dimitrios, Jordan, Jens, Engeli, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adult Analytical methods Anandamide Animal tissues beta-Cyclodextrins - adverse effects beta-Cyclodextrins - pharmacology Biology Blood Circulation - drug effects Blood flow Calibration Catheters Cyclodextrin Cyclodextrins Endocannabinoids - metabolism Ethanol Ethanol - chemistry Experiments Fatty acids Feasibility Studies Female Fluids Glucose - metabolism Glycerol Human tissues Humans Hydrophobicity Lactates Lactic acid Lipolysis - drug effects Lipophilic Male Medical research Medical schools Medicine Metabolic disorders Metabolites Microdialysis Microdialysis - methods Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Musculoskeletal system Neurosurgery Perfusion Perfusion fluids Pharmaceutical sciences Pharmacology Physiology Product safety Protein binding Proteomics Rodents Stability analysis Toxicology Ultrafiltration
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