GSE is a maternal factor involved in active DNA demethylation in zygotes

After fertilization, the sperm and oocyte genomes undergo extensive epigenetic reprogramming to form a totipotent zygote. The dynamic epigenetic changes during early embryo development primarily involve DNA methylation and demethylation. We have previously identified Gse (gonad-specific expression g...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60205-e60205
Hauptverfasser:	Hatanaka, Yuki, Shimizu, Natsumi, Nishikawa, Satoshi, Tokoro, Mikiko, Shin, Seung-Wook, Nishihara, Takuji, Amano, Tomoko, Anzai, Masayuki, Kato, Hiromi, Mitani, Tasuku, Hosoi, Yoshihiko, Kishigami, Satoshi, Matsumoto, Kazuya
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Animals Antisense RNA Biology Blastocyst - cytology Blastocyst - metabolism Chromatin Chromatin - genetics Chromatin - metabolism CpG islands Cytosine - analogs & derivatives Cytosine - metabolism Demethylation Deoxyribonucleic acid DNA DNA Methylation Embryo, Mammalian Embryonic Development Embryos Epigenesis, Genetic Epigenetics Female Fertilization Gene expression Gene Expression Regulation, Developmental Genetic aspects Genomes Germ cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Immunoprecipitation In vitro fertilization Laboratory animals Localization Long Interspersed Nucleotide Elements - genetics Male Mammals Methylation Mice Nanog Homeobox Protein Nuclei Nuclei (cytology) Oct-4 protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Oocytes Pronucleus Protein Binding Proteins Proteins - antagonists & inhibitors Proteins - genetics Proteins - metabolism Reduction Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Sex Factors Sperm University graduates Zygote Zygote - cytology Zygote - metabolism Zygotes
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