The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes
The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphis...
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| creator | Eynon, Nir Nasibulina, Emiliya S Banting, Lauren K Cieszczyk, Pawel Maciejewska-Karlowska, Agnieszka Sawczuk, Marek Bondareva, Elvira A Shagimardanova, Roza R Raz, Maytal Sharon, Yael Williams, Alun G Ahmetov, Ildus I Lucia, Alejandro Birk, Ruth |
| description | The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism.
A large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level.
There were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level).
The FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics. |
| doi_str_mv | 10.1371/journal.pone.0060570 |
| format | Article |
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A large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level.
There were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level).
The FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0060570</identifier><identifier>PMID: 23573268</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Athletes ; Athletic Performance ; Biology ; Body fat ; Case-Control Studies ; Competition ; Data retrieval ; Diabetes ; Disease ; Endurance ; European Continental Ancestry Group ; Exercise ; Female ; Gene polymorphism ; Genetic aspects ; Genetic Association Studies ; Genetic polymorphisms ; Genetics ; Genotypes ; Health aspects ; Health sciences ; Humans ; Laboratories ; Male ; Medicine ; Metabolism ; Nutrition ; Obesity ; Physical fitness ; Poland ; Polymorphism ; Polymorphism, Single Nucleotide ; Proteins ; Proteins - genetics ; Regression analysis ; Russia ; Sequence Analysis, DNA ; Social and Behavioral Sciences ; Spain ; Studies ; Tourism ; Track & field ; Young Adult</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e60570-e60570</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Eynon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Eynon et al 2013 Eynon et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-492a92dcd4403746c834ec35db0c69ae99a3f121c4104a4cc3f86408cb3af6923</citedby><cites>FETCH-LOGICAL-c692t-492a92dcd4403746c834ec35db0c69ae99a3f121c4104a4cc3f86408cb3af6923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616005/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616005/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23573268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eynon, Nir</creatorcontrib><creatorcontrib>Nasibulina, Emiliya S</creatorcontrib><creatorcontrib>Banting, Lauren K</creatorcontrib><creatorcontrib>Cieszczyk, Pawel</creatorcontrib><creatorcontrib>Maciejewska-Karlowska, Agnieszka</creatorcontrib><creatorcontrib>Sawczuk, Marek</creatorcontrib><creatorcontrib>Bondareva, Elvira A</creatorcontrib><creatorcontrib>Shagimardanova, Roza R</creatorcontrib><creatorcontrib>Raz, Maytal</creatorcontrib><creatorcontrib>Sharon, Yael</creatorcontrib><creatorcontrib>Williams, Alun G</creatorcontrib><creatorcontrib>Ahmetov, Ildus I</creatorcontrib><creatorcontrib>Lucia, Alejandro</creatorcontrib><creatorcontrib>Birk, Ruth</creatorcontrib><title>The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism.
A large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level.
There were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level).
The FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Athletes</subject><subject>Athletic Performance</subject><subject>Biology</subject><subject>Body fat</subject><subject>Case-Control Studies</subject><subject>Competition</subject><subject>Data retrieval</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Endurance</subject><subject>European Continental Ancestry Group</subject><subject>Exercise</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic polymorphisms</subject><subject>Genetics</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Physical fitness</subject><subject>Poland</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>Regression analysis</subject><subject>Russia</subject><subject>Sequence Analysis, DNA</subject><subject>Social and Behavioral Sciences</subject><subject>Spain</subject><subject>Studies</subject><subject>Tourism</subject><subject>Track & field</subject><subject>Young 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FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes</title><author>Eynon, Nir ; Nasibulina, Emiliya S ; Banting, Lauren K ; Cieszczyk, Pawel ; Maciejewska-Karlowska, Agnieszka ; Sawczuk, Marek ; Bondareva, Elvira A ; Shagimardanova, Roza R ; Raz, Maytal ; Sharon, Yael ; Williams, Alun G ; Ahmetov, Ildus I ; Lucia, Alejandro ; Birk, Ruth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-492a92dcd4403746c834ec35db0c69ae99a3f121c4104a4cc3f86408cb3af6923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Athletes</topic><topic>Athletic Performance</topic><topic>Biology</topic><topic>Body fat</topic><topic>Case-Control Studies</topic><topic>Competition</topic><topic>Data 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G</au><au>Ahmetov, Ildus I</au><au>Lucia, Alejandro</au><au>Birk, Ruth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-03</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e60570</spage><epage>e60570</epage><pages>e60570-e60570</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism.
A large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level.
There were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level).
The FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23573268</pmid><doi>10.1371/journal.pone.0060570</doi><tpages>e60570</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1330913985 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO Athletes Athletic Performance Biology Body fat Case-Control Studies Competition Data retrieval Diabetes Disease Endurance European Continental Ancestry Group Exercise Female Gene polymorphism Genetic aspects Genetic Association Studies Genetic polymorphisms Genetics Genotypes Health aspects Health sciences Humans Laboratories Male Medicine Metabolism Nutrition Obesity Physical fitness Poland Polymorphism Polymorphism, Single Nucleotide Proteins Proteins - genetics Regression analysis Russia Sequence Analysis, DNA Social and Behavioral Sciences Spain Studies Tourism Track & field Young Adult |
| title | The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A34%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20FTO%20A/T%20polymorphism%20and%20elite%20athletic%20performance:%20a%20study%20involving%20three%20groups%20of%20European%20athletes&rft.jtitle=PloS%20one&rft.au=Eynon,%20Nir&rft.date=2013-04-03&rft.volume=8&rft.issue=4&rft.spage=e60570&rft.epage=e60570&rft.pages=e60570-e60570&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0060570&rft_dat=%3Cgale_plos_%3EA478439910%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330913985&rft_id=info:pmid/23573268&rft_galeid=A478439910&rft_doaj_id=oai_doaj_org_article_a0f3a7758c64469e8748ddf83f7f902d&rfr_iscdi=true |